The effects of intravenous glucose and fructose on insulin levels in sheep

Cookson, S. M. and Godwin, I. R. and McFarlane, J. R. and Kauter, K. G. and Ciller, U. and Ciller, I. M. and Metcalfe, K. E. (2008) The effects of intravenous glucose and fructose on insulin levels in sheep. In: Proceedings of the Nutrition Society of Australia Conference, 30 Nov - 3 Dec 2008, Glenelg, South Australia.

Text (Abstract)
Cookson_Godwin_McFarlane_Kauter_Ciller_Ciller_Metcalfe_APJCN_ 17 _S3-80_2008_Abstract.pdf

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A high fructose diet is known to cause insulin resistance in a wide range of mammals. An acute oral loading of fructose has no effect on the insulin level of normal or diabetic animals. No studies have investigated the effects of intravenous fructose loading in sheep, a species which generally derives all blood glucose from gluconeogenesis.
Objective – To compare the effects of a bolus loading of intravenous fructose and glucose on blood glucose and insulin levels in sheep.
Design – Ten crossbred wethers were fed lucerne chaff ad libitum. They were given either 0.24 g/kg of glucose or fructose intravenously in a single bolus dose. Plasma glucose, fructose and insulin were measured in serial blood samples for the following six hours.
Outcomes – As expected glucose infusion resulted in a substantial rise in blood glucose and a modest increase in
insulin level. The fructose infusion led to very a modest rise in blood fructose and large increase in plasma insulin level with a resultant fall in blood glucose level.
Conclusion – Sheep respond differently to other mammals to fructose loading. Intravenous fructose stimulates insulin release in sheep. This response is different to most other mammals which show insulin refractoriness to
fructose loading.

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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Poster)
Refereed: No
Item Status: Live Archive
Faculty/School / Institute/Centre: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 30 Sep 2014 20:35
Last Modified: 30 Sep 2014 20:35
Uncontrolled Keywords: sheep; fructose; insulin resistance
Fields of Research : 06 Biological Sciences > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified
11 Medical and Health Sciences > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences

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