Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes on outcomes of elective gastrointestinal surgery

Osland, Emma and Hossain, Md. Belal and Khan, Shahjahan and Memon, Muhammed A. (2010) Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes on outcomes of elective gastrointestinal surgery. In: 10th Islamic Countries Conference on Statistical Sciences (ICCSS-10): Statistics for Development and Good Governance, 20-23 Dec 2009, Cairo, Egypt.


Providing tube feeds or liquid oral supplements containing additional arginine and/or omega-3 fatty acids and RNA – often referred to as 'immunonutrition' and more recently
'pharmaconutrition' – has been proposed as a strategy to decrease postoperative complications and duration of hospital length of stay for elective surgical patients. However outcomes of individual studies vary and the purported benefits remain controversial. A meta-analysis on this topic was recently published (Zheng et al., 2007), however further randomised controlled trials
on this topic have appeared in the literature since this time. This meta-analysis has been undertaken to update the previously published meta-analysis and to attempt to elucidate the potential benefit of providing immune-enhanced nutrition in surgical patients. A search of
electronic databases identified all RCTs comparing the use of pre and/or perioperative immunonutrition with standard nutrition provision in elective adult surgical patients between 1990 and 2008. The meta-analysis was prepared in accordance with the Quality of Reporting of
Meta-analyses (QUOROM) statement. The variables analysed included mortality, total complications, infective complications, anastomotic leak (where applicable), and length of hospital stay. 20 distinct studies were identified that met inclusion criteria involving 1966
patients (immunonutrition n= 1048; standard nutrition n= 918). The provision of immunonutrition was shown to be associated with significant reductions in the incidence of total postoperative complications (OR 0.59, CI 0.41, 0.83, p=0.0023, Q=51.5, p=0.0001, I2 = 59%, CI 34.8%, 74.5%), postoperative infective complications (OR 0.49, CI 37, 64, p=0.0001, Q=25.2, p=0.1939 , I2 = 23%, CI 0%, 53.3%), anastomotic breakdown (OR 0.51, CI 0.31, 0.84 , p=0.0085, Q= 6.31, p=0.03 , I2 = 0%, CI 0%, 7.3%) when compared to standard nutritional provision. No effect of the differences in feed product formulation were seen with relation to mortality (OR 0.94, CI 0.49, 1.8, p=0.861, Q=4.49, p=0.99, I2 = 0%, CI 0%, 0%) or length of
hospital stay (WMD -2.52, CI -3.71, -1.33, p=0.0001, Q= 219, p=0.0001, I2 = 90.2%, CI 87.5%, 93.4%). This meta-analysis lends strong support to the beneficial effects of immune-enhanced nutrition in the management of elective gastrointestinal surgical patients.

Statistics for USQ ePrint 9325
Statistics for this ePrint Item
Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Paper)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author version not held. Fulltext citation: Osland, E; Hossain, M B; Khan, S; and Memon, M A (2010). PRELIMINARY RESULTS OF A META-ANALYSIS EVALUATING THE EFFECT OF IMMUNONUTRITION ON OUTCOMES OF ELECTIVE GASTROINTESTINAL SURGERY. Proceedings of the Tenth Islamic Countries Conference on Statistical Sciences (ICCS-X), Volume I, 132–139.
Depositing User: Professor Shahjahan Khan
Faculty / Department / School: Historic - Faculty of Sciences - Department of Maths and Computing
Date Deposited: 30 Jan 2011 00:09
Last Modified: 11 Feb 2015 04:25
Uncontrolled Keywords: meta-analysis; surgery; immunonutrition; pharmaconutrition; surgical complications human
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111104 Public Nutrition Intervention
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111102 Dietetics and Nutrigenomics
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111199 Nutrition and Dietetics not elsewhere classified
Socio-Economic Objective: C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders

Actions (login required)

View Item Archive Repository Staff Only