The design and investigation of model based internal model control for the regulation of hypnosis

Abdulla, Shahab and Wen, Peng and Xiang, Wei (2010) The design and investigation of model based internal model control for the regulation of hypnosis. In: IEEE/NANOMED 2010: Promoting Good Health with Nanotechnology, 5-9 Dec 2010, Hong Kong, China.

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The manual control of anaesthesia is still the dominant practice during surgery. An increasing number of studies have been conducted to explore the possibility of automating this process. The major difficulty in the design of closed-loop control during anaesthesia is the inherent patient variability due to differences in demographic and drug tolerance. These discrepancies are translated into the differences in pharmacokinetics (PK), and pharmacodynamics (PD). This study develops patient dose-response models and provides an adequate drug administration regimen for the anaesthesia to avoid under or over dosing of the patients. The controllers are designed to compensate for patients inherent drug response variability, to achieve the best output disturbance rejection, and to maintain optimal set point response. The results are evaluated and compared with traditional PID controller. The performance is confirmed in our simulation.

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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Paper)
Refereed: Yes
Item Status: Live Archive
Additional Information: Accepted version deposited in accordance with the copyright policy of the publisher.
Faculty/School / Institute/Centre: Historic - Faculty of Engineering and Surveying - Department of Electrical, Electronic and Computer Engineering
Date Deposited: 04 Jan 2011 04:58
Last Modified: 14 Oct 2014 04:51
Uncontrolled Keywords: internal model control; depth of anaesthesia; PID controller; anaesthesia control; closed loop control; drug response variability; drug tolerance; hypnosis regulation; inherent patient variability; model-based internal model control; optimal set point response; output disturbance rejection; patient dose-response models; pharmacodynamics; pharmacokinetics; surgery; brain modeling; plasmas
Fields of Research : 09 Engineering > 0903 Biomedical Engineering > 090302 Biomechanical Engineering
01 Mathematical Sciences > 0102 Applied Mathematics > 010202 Biological Mathematics
11 Medical and Health Sciences > 1103 Clinical Sciences > 110301 Anaesthesiology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1109/NANOMED.2010.5749833

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