The role of leptin in reproduction and fertility

McFarlane, Jim and Kauter, Kate and Panwar, Shalini (2008) The role of leptin in reproduction and fertility. In: Australian College of Veterinary Scientists 2008 Annual Conference, 3-6 Jul 2008, Surfers Paradise, Australia.

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Leptin was originally identified as a peripheral satiety signal made by fat cells and it was proposed that as fat accumulates leptin is secreted proportionally. Leptin then crosses the blood brain barrier and signals to the hypothalamus suppressing appetite and increasing energy expenditure as it rises. It is evident that if the leptin gene or its receptor is disrupted them morbid obesity occurs. However, obesity in humans is very rarely caused by a disruption of the leptin gene or its receptor, and in many species a good correlation exists between leptin concentrations in plasma with the degree of obesity. This early finding was unexpected and led to the leptin resistance hypothesis. Further studies have revealed that leptin actually appears to be almost ubiquitously expressed in many tissues. Unfortunately despite the accumulation of a vast literature leptin still appears to be regarded as a peripheral satiety signal although the data to support this hypothesis is not substantial.

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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Poster)
Refereed: No
Item Status: Live Archive
Additional Information: No indication of copyright restrictions.
Faculty/School / Institute/Centre: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 05 Oct 2014 02:06
Last Modified: 13 Jun 2016 23:32
Fields of Research : 06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified
07 Agricultural and Veterinary Sciences > 0702 Animal Production > 070206 Animal Reproduction
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
B Economic Development > 83 Animal Production and Animal Primary Products > 8303 Livestock Raising > 830399 Livestock Raising not elsewhere classified

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