An investigation on the antimicrobial activity of Andrographis paniculata extracts and Andrographolide in vitro

Xu, Youhong and Marshall, Raymond L. and Mukkur, T. K. S. (2006) An investigation on the antimicrobial activity of Andrographis paniculata extracts and Andrographolide in vitro. Asian Journal of Plant Sciences, 5 (3). pp. 527-530. ISSN 1682-3974


An aqueous and two ethanolic extracts of Andrographis paniculata, used in traditional Chinese, Thai and Indian medicine and andrographolide, an active principle of Andrographis paniculata, were investigated for their antimicrobial activity against nine bacterial species including Salmonella Typhumurium, Escherichia coli, Shigella sonnei, Staphylocuccus aureus, Pseudomonas Aeruginosa, Streptococcus pneumoniae, Streptococcus pyogenes, Legionella pneumophila and Bordetella pertussis, using the disc diffusion method. Of all tested concentrations, direct antimicrobial activity of the two ethanolic Andrographis paniculata extracts was observed for only two human pathogens, Legionella pneumophila and Bordetella pertussis. However, no antibacterial activity of andrographolide against any of the pathogens tested in this investigation was observed. Given that the TLC of Andrographis paniculata extracts showed that andrographolide was present in all the three Andrographis paniculata extracts, it was concluded that the observed antimicrobial activity was due to other active principle(s) present in the extracts used in this investigation.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author verison not held.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 30 Apr 2010 07:16
Last Modified: 02 Jul 2013 23:51
Uncontrolled Keywords: Andrographis paniculata; andrographolide; antimicrobial; disc diffusion, medicinal plant extracts
Fields of Research : 06 Biological Sciences > 0605 Microbiology > 060501 Bacteriology
11 Medical and Health Sciences > 1104 Complementary and Alternative Medicine > 110404 Traditional Chinese Medicine and Treatments
06 Biological Sciences > 0605 Microbiology > 060502 Infectious Agents
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences

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