Intraarticular corticosteroid for treatment of osteoarthritis of the knee

Bellamy, Nicholas and Campbell, Jane and Welch, Vivian and Gee, Travis L. and Bourne, Robert and Wells, George A. (2008) Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database of Systematic Reviews (2). pp. 1-120. ISSN 1469-493X


BACKGROUND: Osteoarthritis (OA) is a common joint disorder. In the knee, injections of corticosteroids into the joint (intra-articular (IA)) may relieve inflammation, and reduce pain and disability. OBJECTIVES: To evaluate the efficacy and safety of IA corticosteroids in treatment of OA of the knee.
SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 2, 2003), MEDLINE, EMBASE, PREMEDLINE (all to July 2003), and Current Contents (Sept 2000). Specialised journals, trial reference lists and review articles were handsearched.
SELECTION CRITERIA: Randomised controlled trials of IA corticosteroids for patients with OA of the knee: single/double blind, placebo-based/comparative studies, reporting at least one core OMERACT III outcome measure. DATA COLLECTION AND ANALYSIS: Methodological quality of trials was assessed, and data were extracted in duplicate. Fixed effect and random effects models, giving weighted mean differences (WMD), were used for continuous variables. Dichotomous outcomes were analysed by relative risk
AUTHORS CONCLUSIONS : The short-term benefit of IA corticosteroids in treatment of knee OA is well established, and few side effects have been reported. Longer
term benefits have not been confirmed based on the RevMan analysis. The response to HA products appears more durable. In this review, some discrepancies were observed between the RevMan 4.2 analysis and the original publication. These are likely the result of using secondary rather than primary data and the statistical methods available in RevMan 4.2. Future trials should have standardised
outcome measures and assessment times, run longer, investigate different patient subgroups, and clinical predictors of response (those associated with inflammation and structural damage)

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Abstract only available. PubMed ID 15846755 pp.CD005328.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Psychology
Date Deposited: 25 May 2010 02:31
Last Modified: 02 Jul 2013 23:51
Uncontrolled Keywords: corticosteroid ; intraarticular: knee arthritis
Fields of Research : 11 Medical and Health Sciences > 1103 Clinical Sciences > 110322 Rheumatology and Arthritis

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