Structural and functional characteristics of the promoter regions of the genes on human chromosome 22

Liu, Guang Bin (2007) Structural and functional characteristics of the promoter regions of the genes on human chromosome 22. In: 5th Asia-Pacific Bioinformatics Conference (APBC2007), 15-17, Jan 2007, Hong Kong, Hong Kong.

[img]
Preview
Text (Proceedings Front matter)
Liu_2007_Proceedings.pdf

Download (42Kb) | Preview

Abstract

The base composition pattern in the putative promoter region (PPRs) up to 5 Kb lengths of 682 human genes on Chromosome 22 (Chr22) was examined. Two-dimensional (2-D) and three-dimensional (2-D) functions were designed to delineate the DNA base composition, with four major patterns identified. It is found that 17.6% genes include TATA box, 28.0% GC box, 18.9% CAAT box and 38.4% CpG islands, and approximately 10 % genes have one of four putative initiator motifs. The occurrence of the promoter elements is tightly associated with the base composition features in the promoter regions, and the associations of the base composition features with occurrence of the promoter elements in the promoter regions mediate tissue-wide expression of the genes in human. The occurrence of two or more promoter elements in the promoter regions is required for the medium- and wide-range expression profiles of the human genes on Chr22. Thus, the reported data shed light on the characteristics of the PPRs of the human genes on Chr22, which may improve our understanding of regulatory roles of the PPRs with occurrence of the promoter elements in gene expression.


Statistics for USQ ePrint 7620
Statistics for this ePrint Item
Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Poster)
Refereed: Yes
Item Status: Live Archive
Additional Information: Unable to source copy of publication.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 14 Dec 2017 03:46
Last Modified: 15 Dec 2017 00:02
Uncontrolled Keywords: genetics; chromosome 22; human DNA
Fields of Research : 06 Biological Sciences > 0604 Genetics > 060407 Genome Structure and Regulation
06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060102 Bioinformatics
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
URI: http://eprints.usq.edu.au/id/eprint/7620

Actions (login required)

View Item Archive Repository Staff Only