Supervised exercise training combined with ginkgo biloba treatment for patients with peripheral arterial disease

Wang, Jianxiong and Zhou, Shi and Bronks, Roger and Graham, John and Myers, Stephen (2007) Supervised exercise training combined with ginkgo biloba treatment for patients with peripheral arterial disease. Clinical Rehabilitation, 21 (7). pp. 579-586. ISSN 0269-2155


Objectives: To evaluate whether a combination of supervised exercise training and ginkgo biloba treatment is a better treatment than exercise training alone for patients with peripheral arterial disease. Design: A 24-week double-blind, placebo-controlled ginkgo biloba trial with the first 12-week period as a non-exercise control stage and the second 12-week period as an exercise training stage. Setting: Exercise physiology laboratory. Subjects: Twenty-two subjects with peripheral arterial disease. Interventions: The subjects were randomly allocated into a ginkgo or a placebo group. During the first stage, the ginkgo group ingested standardized ginkgo biloba tablets with a daily dosage of 240mg, while the placebo group received placebo tablets. During the second stage, all subjects engaged in a supervised treadmill-walking programme while continuing to take the same dosage of ginkgo biloba or placebo tablets. Main measures: Walking capacity on treadmill, oxygen consumption during exercise, peripheral haemodynamics and blood viscosity were measured at baseline, and after the first and the second stages of treatment. Results: The ginkgo group did not show significant changes in most of the measured variables after each stage of treatment, except that the maximal walking time was significantly increased after the combined treatment (from 236 ± 112 seconds to 557 ± 130 seconds, P < 0.001). However, similar response was also found in the placebo group after exercise training (from 384 ± 125 seconds to 820 ± 146 seconds, P < 0.001). Conclusion: Supervised exercise training combined with ginkgo biloba treatment did not produce greater beneficial effects than exercise training alone in patients with peripheral arterial disease.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Awaiting Author's version, which may be deposited in accordance with the copyright policy of the publisher.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 17 Apr 2010 12:34
Last Modified: 02 Jul 2013 23:46
Uncontrolled Keywords: supervised exercise training; ginkgo biloba; peripheral arterial deisease
Fields of Research : 11 Medical and Health Sciences > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified
11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110202 Haematology
Socio-Economic Objective: C Society > 92 Health > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine
C Society > 92 Health > 9202 Health and Support Services > 920201 Allied Health Therapies (excl. Mental Health Services)
Identification Number or DOI: 10.1177/0269215507075205

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