Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis

Jastroch, M. and Withers, K. W. and Taudien, S. and Frappell, P. B. and Helwig, M. and Fromme, T. and Hirschberg, V. and Heldmaier, G. and McAllan, B. M. and Firth, B. T. and Burmester, T. and Platzer, M. and Klingenspor, M. (2008) Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis. Physiological Genomics, 32 (2). pp. 161-169. ISSN 1094-8341


Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the cold. The emergence of this thermogenic organ during mammalian evolution remained unknown as the identification of UCP1 in marsupials failed so far. Here, we unequivocally identify the marsupial UCP1 ortholog in a genomic library of Monodelphis domestica. In South American and Australian marsupials, UCP1 is exclusively expressed in distinct adipose tissue sites and appears to be recruited by cold exposure in the smallest species under investigation (Sminthopsis crassicaudata). Our data suggest that an archetypal brown adipose tissue was present at least
150 million yr ago allowing early mammals to produce endogenous heat in the cold, without dependence on shivering and locomotor activity.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Deposit not permitted by publisher.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 09 Apr 2010 09:03
Last Modified: 09 Oct 2013 06:32
Uncontrolled Keywords: marsupials; brown adipose tissue; cold acclimation
Fields of Research : 06 Biological Sciences > 0603 Evolutionary Biology > 060305 Evolution of Developmental Systems
06 Biological Sciences > 0606 Physiology > 060604 Comparative Physiology
07 Agricultural and Veterinary Sciences > 0707 Veterinary Sciences > 070702 Veterinary Anatomy and Physiology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
Identification Number or DOI: 10.1152/physiolgenomics.00183.2007

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