Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation

Wong, Rachel H. X. and Howe, Peter R. C. (2018) Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation. Nutrients, 10 (9):1160. pp. 1-10.

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Abstract

Pre-clinical data and human trials indicate that resveratrol supplementation may help to counteract diabetes. Several mechanisms of action have been proposed to explain its metabolic benefits, including activation of sirtuins and estrogen receptors (ER) to promote glucose transporter type-4 (GLUT4) translocation and increase glucose uptake. Resveratrol can also enhance vasodilator function, yet the possibility that this action might help to alleviate insulin resistance in type-2 diabetes mellitus has received little attention. In this brief review we propose that, by restoring impaired endothelium-dependent vasodilatation in insulin resistant individuals resveratrol increases blood perfusion of skeletal muscle, thereby facilitating glucose delivery and utilization with resultant improvement of insulin sensitivity. Thus, circulatory improvements by vasoactive nutrients such as resveratrol may play a role in preventing or alleviating insulin resistance.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Current - Institute for Resilient Regions
Faculty/School / Institute/Centre: Current - Institute for Resilient Regions
Date Deposited: 06 Jul 2022 02:58
Last Modified: 07 Jul 2022 03:19
Uncontrolled Keywords: diabetes; insulin resistance; microvascular function; vasoactive nutrients; resveratrol
Fields of Research (2008): 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111199 Nutrition and Dietetics not elsewhere classified
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321099 Nutrition and dietetics not elsewhere classified
Identification Number or DOI: https://doi.org/10.3390/nu10091160
URI: http://eprints.usq.edu.au/id/eprint/49415

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