Cognitive Deficits in Type-1 Diabetes: Aspects of Glucose, Cerebrovascular and Amyloid Involvement

Pickering, Justin and Wong, Rachel and Al-Salami, Hani and Lam, Virginie and Takechi, Ryu (2021) Cognitive Deficits in Type-1 Diabetes: Aspects of Glucose, Cerebrovascular and Amyloid Involvement. Pharmaceutical Research, 38. pp. 1477-1484. ISSN 0724-8741


Abstract

The evidence shows that individuals with type-1 diabetes mellitus (T1DM) are at greater risk of accelerated cognitive impairment and dementia. Although, to date the mechanisms are largely unknown. An emerging body of literature indicates that dysfunction of cerebral neurovascular network and plasma dyshomeostasis of soluble amyloid-β in association with impaired lipid metabolism are central to the onset and progression of cognitive deficits and dementia. However, the latter has not been extensively considered in T1DM. Therefore, in this review, we summarised the literature concerning altered lipid metabolism and cerebrovascular function in T1DM as an implication for potential pathways leading to cognitive decline and dementia.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: Current - Institute for Resilient Regions
Faculty/School / Institute/Centre: Current - Institute for Resilient Regions
Date Deposited: 22 Jun 2022 05:25
Last Modified: 29 Jun 2022 00:49
Uncontrolled Keywords: amyloid-beta, cerebrovascular dysfunction, hyperglycemia, type 1 diabetes
Fields of Research (2008): 11 Medical and Health Sciences > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320999 Neurosciences not elsewhere classified
Identification Number or DOI: https://doi.org/10.1007/s11095-021-03100-1
URI: http://eprints.usq.edu.au/id/eprint/49250

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