Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids

Brook, Emily and Mamo, John and Wong, Rachel and Al-Salami, Hani and Falasca, Marco and Lam, Virginie and Takechi, Ryusuke (2019) Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids. Pharmacological Research, 141. pp. 291-297. ISSN 1043-6618


Abstract

Type-2 diabetes (T2D) increases the risk of dementia by ˜5-fold, however the mechanisms by which T2D increases dementia risk remain unclear. Evidence suggests that the heightened inflammation and oxidative stress in T2D may lead to disruption of the blood-brain barrier (BBB), which precedes premature cognitive decline. Studies show that vascular-targeted anti-inflammatory treatments protect the BBB by attenuating neuroinflammation, and in some studies attenuate cognitive decline. Yet, this potential pathway is understudied in T2D-associated cognitive impairment. In recent years, therapeutic potential of cannabinoids has gained much interest. The two major cannabinoids, cannabidiol and tetrahydrocannabinol, exert anti-inflammatory and vascular protective effects, however few studies report their potential for reversing BBB dysfunction, particularly in T2D. Therefore, in this review, we summarize the current findings on the role of BBB dysfunction in T2D-associated dementia and consider the potential therapeutic use of cannabinoids as a protectant of cerebrovascular BBB protection.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: Current - Institute for Resilient Regions
Faculty/School / Institute/Centre: Current - Institute for Resilient Regions
Date Deposited: 12 Jun 2022 23:24
Last Modified: 13 Jun 2022 01:30
Uncontrolled Keywords: Blood-brain barrier, Diabetes, Dementia, Cannabidiol, Cognitive impairment, Inflammation, Tetrahydrocannabidiol
Fields of Research (2008): 11 Medical and Health Sciences > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320999 Neurosciences not elsewhere classified
Identification Number or DOI: https://doi.org/10.1016/j.phrs.2019.01.009
URI: http://eprints.usq.edu.au/id/eprint/48928

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