Auditory event-related potentials in methadone substituted opiate users

Wang, Grace Y. ORCID: and Kydd, Robert and Russell, Bruce R. (2015) Auditory event-related potentials in methadone substituted opiate users. Journal of Psychopharmacology, 29 (9). pp. 983-995. ISSN 0269-8811


The effects of methadone maintenance treatment (MMT) on neurophysiological function are unclear. Using an auditory oddball paradigm, event-related potential (ERP) amplitudes and latencies were measured in 32 patients undertaking MMT, 17 opiate users who were addicted but not receiving substitution treatment and 25 healthy control subjects. Compared with healthy control subjects, the MMT and opiate user groups showed an increased P200 amplitude in response to target stimuli. The opiate user group also exhibited a decreased amplitude and an increased latency of N200, and a greater number of task-related errors than either healthy control subjects or patients undertaking MMT. There were no significant group differences in the P300 amplitude. However, it is noteworthy that the frontal P300 amplitude of the MMT group was greater than that of opiate users or healthy controls. Our findings suggest that altered sensory information processing associated with a history of opiate use remains in patients undertaking MMT. However, there are less marked ERP abnormalities in those receiving MMT than in active opiate users. The deficits in information processing associated with illicit opiate use are likely to be reduced during MMT.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 18 May 2022 03:12
Last Modified: 18 May 2022 03:12
Uncontrolled Keywords: cognitive function; electroencephalographic; Event related potential; Methadone maintenance treatment; opiates
Fields of Research (2020): 52 PSYCHOLOGY > 5202 Biological psychology > 520205 Psychopharmacology
Socio-Economic Objectives (2020): 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions
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