Quantitative EEG and Low-Resolution Electromagnetic Tomography (LORETA) Imaging of Patients Undergoing Methadone Treatment for Opiate Addiction

Wang, Grace Y. ORCID: https://orcid.org/0000-0003-2063-031X and Kydd, Robert R. and Russell, Bruce R. (2016) Quantitative EEG and Low-Resolution Electromagnetic Tomography (LORETA) Imaging of Patients Undergoing Methadone Treatment for Opiate Addiction. Clinical EEG and Neuroscience, 47 (3). pp. 180-187. ISSN 1550-0594


Abstract

Methadone maintenance treatment (MMT) has been used as a treatment for opiate dependence since the mid-1960s. Evidence suggests that methadone binds to mu opiate receptors as do other opiates and induces changes in neurophysiological function. However, little is known, about how neural activity within the higher frequency gamma band (>30 Hz) while at rest changes in those stabilized on MMT despite its association with the excitation-inhibition balance within pyramidal-interneuron networks. Our study investigated differences in resting gamma power (37-41 Hz) between patients undergoing MMT for opiate dependence, illicit opiate users, and healthy controls subjects. Electroencephalographic data were recorded from 26 sites according to the international 10-20 system. Compared with the healthy controls subjects, people either undergoing MMT (mean difference [MD] = 0.32, 95% CI = 0.09-0.55, P <.01) or currently using illicit opiates (MD = 0.31, 95% CI = 0.06-0.56, P =.01) exhibited significant increased gamma power. The sLORETA (standardized low-resolution electromagnetic tomography) between-group comparison revealed dysfunctional neuronal activity in the occipital, parietal, and frontal lobes in the patients undergoing MMT. A more severe profile of dysfunction was observed in those using illicit opiates. Our findings suggest that long-term exposure to opioids is associated with disrupted resting state network, which may be reduced after MMT.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 18 May 2022 01:19
Last Modified: 25 May 2022 01:42
Uncontrolled Keywords: EEG gamma; LORETA; methadone treatment; opiate addiction
Fields of Research (2020): 52 PSYCHOLOGY > 5202 Biological psychology > 520205 Psychopharmacology
Socio-Economic Objectives (2020): 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions
Identification Number or DOI: https://doi.org/10.1177/1550059415586705
URI: http://eprints.usq.edu.au/id/eprint/48413

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