Effect of drug-related cues on response inhibition through abstinence: A pilot study in male heroin abstainers

Su, Bobo and Yang, Ling and Wang, Grace Y. ORCID: https://orcid.org/0000-0003-2063-031X and Wang, Sha and Li, Shaomei and Cao, Hua and Zhang, Yan (2017) Effect of drug-related cues on response inhibition through abstinence: A pilot study in male heroin abstainers. American Journal of Drug and Alcohol Abuse, 43 (6). pp. 664-670. ISSN 0095-2990


Abstract

Background: Chronic heroin use can cause a deficit of inhibitory function, leading to a loss of control over drug use. Exposure to drug-related cues is considered as one of the contributing factors. However, it is unclear whether there are dynamic changes on the effect of drug-related cues on response inhibition following prolonged abstinence. Objective: The present study investigated the effect of drug-related cues on response inhibition in heroin abstainers at different abstinent phases. Methods: 26 shorter-term (2–6 months) and 26 longer-term (19–24 months) male heroin abstainers performed on a modified two-choice Oddball task, which included two conditions: in the cued condition, neutral pictures served as the background of standard stimuli (yellow frame) and heroin-related pictures served as the background of deviant stimuli (blue frame), reversed in the controlled conditions. Results: Compared to longer-term abstainers, mean reaction time (RT) for drug deviants in shorter-term abstainers was significantly longer. Shorter-term abstainers also showed markedly slower response to neutral deviants relative to drug deviants, but this tendency was not observed in longer-term abstainers. Nevertheless, both groups had similar RT for standard stimuli regardless of their paired background pictures. Conclusion: Effect of drug-related cues on response inhibition remains at the early stage of abstinence; however, this effect may be reduced following a longer period of drug abstinence. Our findings highlight the importance of assessing and improving the ability of inhibiting drug-related cue reactivity during treatment.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 16 May 2022 01:44
Last Modified: 30 May 2022 01:50
Uncontrolled Keywords: drug-related cues; Heroin abstainers; response inhibition; two-choice Oddball task
Fields of Research (2020): 52 PSYCHOLOGY > 5202 Biological psychology > 520203 Cognitive neuroscience
Socio-Economic Objectives (2020): 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions
Identification Number or DOI: https://doi.org/10.1080/00952990.2017.1283695
URI: http://eprints.usq.edu.au/id/eprint/48412

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