Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers

Su, Bobo and Wang, Sha and Sumich, Alexander and Li, Shaomei and Yang, Ling and Cai, Yueyue and Wang, Grace Y. ORCID: https://orcid.org/0000-0003-2063-031X (2017) Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers. Psychopharmacology, 234 (21). pp. 3195-3205. ISSN 0033-3158


Abstract

Rationale: Chronic heroin use can cause deficits in response inhibition, leading to a loss of control over drug use, particularly in the context of drug-related cues. Unfortunately, heightened incentive salience and motivational bias in response to drug-related cues may exist following abstinence from heroin use. Objectives: The present study aimed to examine the effect of drug-related cues on response inhibition in long-term heroin abstainers. Methods: Sixteen long-term (8–24 months) male heroin abstainers and 16 male healthy controls completed a modified two-choice oddball paradigm, in which a neutral “chair” picture served as frequent standard stimuli; the neutral and drug-related pictures served as infrequent deviant stimuli of different conditions respectively. Event-related potentials were compared across groups and conditions. Results: Our results showed that heroin abstainers exhibited smaller N2d amplitude (deviant minus standard) in the drug cue condition compared to the neutral condition, due to smaller drug-cue deviant-N2 amplitude compared to neutral deviant-N2. Moreover, heroin abstainers had smaller N2d amplitude compared with the healthy controls in the drug cue condition, due to the heroin abstainers having reduced deviant-N2 amplitude compared to standard-N2 in the drug cue condition, which reversed in the healthy controls. Conclusions: Our findings suggested that heroin addicts still show response inhibition deficits specifically for drug-related cues after longer-term abstinence. The inhibition-related N2 modulation for drug-related could be used as a novel electrophysiological index with clinical implications for assessing the risk of relapse and treatment outcome for heroin users.


Statistics for USQ ePrint 48410
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 18 May 2022 01:41
Last Modified: 30 May 2022 01:45
Uncontrolled Keywords: Drug-related cues; Event-related potentials; Heroin abstainers; Response inhibition; Two-choice oddball task
Fields of Research (2020): 52 PSYCHOLOGY > 5202 Biological psychology > 520205 Psychopharmacology
Socio-Economic Objectives (2020): 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions
Identification Number or DOI: https://doi.org/10.1007/s00213-017-4707-5
URI: http://eprints.usq.edu.au/id/eprint/48410

Actions (login required)

View Item Archive Repository Staff Only