Associations between immunological function and memory recall in healthy adults

Wang, Grace Y. ORCID: and Taylor, Tamasin and Sumich, Alexander and Merien, Fabrice and Borotkanics, Robert and Wrapson, Wendy and Krageloh, Chris and Siegert, Richard J. (2017) Associations between immunological function and memory recall in healthy adults. Brain and Cognition, 119. pp. 39-44. ISSN 0278-2626


Studies in clinical and aging populations support associations between immunological function, cognition and mood, although these are not always in line with animal models. Moreover, very little is known about the relationship between immunological measures and cognition in healthy young adults. The present study tested associations between the state of immune system and memory recall in a group of relatively healthy adults. Immediate and delayed memory recall was assessed in 30 participants using the computerised cognitive battery. CD4, CD8 and CD69 subpopulations of lymphocytes, Interleukin-6 (IL-6) and cortisol were assessed with blood assays. Correlation analysis showed significant negative relationships between CD4 and the short and long delay memory measures. IL-6 showed a significant positive correlation with long-delay recall. Generalized linear models found associations between differences in all recall challenges and CD4. A multivariate generalized linear model including CD4 and IL-6 exhibited a stronger association. Results highlight the interactions between CD4 and IL-6 in relation to memory function. Further study is necessary to determine the underlying mechanisms of the associations between the state of immune system and cognitive performance.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 16 May 2022 01:20
Last Modified: 30 May 2022 01:42
Uncontrolled Keywords: CD4; Immunological measures; Interleukin-6; Memory; T lymphocytes
Fields of Research (2020): 52 PSYCHOLOGY > 5202 Biological psychology > 520203 Cognitive neuroscience
Socio-Economic Objectives (2020): 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions
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