An overview of microneedle applications, materials, and fabrication methods

Faraji Rad, Zahra ORCID: https://orcid.org/0000-0001-6528-5965 and Prewett, Philip and Davies, Graham (2021) An overview of microneedle applications, materials, and fabrication methods. Beilstein Journal of Nanotechnology, 12. pp. 1034-1046.

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Abstract

Microneedle-based microdevices promise to expand the scope for delivery of vaccines and therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics - so-called theranostics. Unskilled and painless applications of microneedle patches for blood collection or drug delivery are two of the advantages of microneedle arrays over hypodermic needles. Developing the necessary microneedle fabrication processes has the potential to dramatically impact the health care delivery system by changing the landscape of fluid sampling and subcutaneous drug delivery. Microneedle designs which range from sub-micron to millimetre feature sizes are fabricated using the tools of the microelectronics industry from metals, silicon, and polymers. Various types of subtractive and additive manufacturing processes have been used to manufacture microneedles, but the development of microneedle-based systems using conventional subtractive methods has been constrained by the limitations and high cost of microfabrication technology. Additive manufacturing processes such as 3D printing and two-photon polymerization fabrication are promising transformative technologies developed in recent years. The present article provides an overview of microneedle systems applications, designs, material selection, and manufacturing methods.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Mechanical and Electrical Engineering (1 Jul 2013 - 31 Dec 2021)
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Mechanical and Electrical Engineering (1 Jul 2013 - 31 Dec 2021)
Date Deposited: 02 Mar 2022 02:14
Last Modified: 02 Mar 2022 02:14
Uncontrolled Keywords: drug delivery; microelectromechanical systems (MEMS); microfabrication; microneedles; point-of-care diagnostics
Fields of Research (2020): 40 ENGINEERING > 4003 Biomedical engineering > 400305 Biomedical instrumentation
40 ENGINEERING > 4003 Biomedical engineering > 400303 Biomechanical engineering
40 ENGINEERING > 4003 Biomedical engineering > 400302 Biomaterials
Identification Number or DOI: https://doi.org/10.3762/bjnano.12.77
URI: http://eprints.usq.edu.au/id/eprint/47112

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