Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques

Faraji Rad, Zahra ORCID: https://orcid.org/0000-0001-6528-5965 and Prewett, Philip and Davies, Graham (2021) Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques. Manufacturing Letters, 30. pp. 39-43.


Abstract

In recent years, interest in microneedle devices for drug and vaccine delivery and point-of-care diagnostics has grown due to low cost, convenience and minimal invasiveness. A cluster of miniature needles on a small patch could enhance the quality of human health care, revolutionizing test and drug and vaccine delivery systems. However, current fabrication methods are not viable for cost-effective large-scale manufacture. This study reports fabrication of ultra-sharp microneedles with microfluidic channels using two-photon polymerization (2PP) which enables flexible designs with resolution down to 100 nm. The technique is ideally suited to prototyping and the fabrication of master molds from which elastomeric negative-molds have been used in a rapid micromolding technique to make batches of ultra-sharp microneedles. This micromolding process has mass manufacturing potential.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Mechanical and Electrical Engineering (1 Jul 2013 - 31 Dec 2021)
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Mechanical and Electrical Engineering (1 Jul 2013 - 31 Dec 2021)
Date Deposited: 02 Mar 2022 01:50
Last Modified: 17 Mar 2022 03:30
Uncontrolled Keywords: Drug delivery; Micro/nanofabrication; Micromolding; Microneedles; Point-of-care diagnostics; Two-photon polymerization
Fields of Research (2020): 40 ENGINEERING > 4014 Manufacturing engineering > 401401 Additive manufacturing
40 ENGINEERING > 4003 Biomedical engineering > 400303 Biomechanical engineering
40 ENGINEERING > 4003 Biomedical engineering > 400302 Biomaterials
Identification Number or DOI: https://doi.org/10.1016/j.mfglet.2021.10.007
URI: http://eprints.usq.edu.au/id/eprint/47111

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