High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays

Faraji Rad, Zahra ORCID: https://orcid.org/0000-0001-6528-5965 and Prewett, Philip and Davies, Graham (2021) High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays. Microsystems & Nanoengineering, 7 (1):71. pp. 1-17.

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Abstract

Microneedle patches have received much interest in the last two decades as drug/vaccine delivery or fluid sampling systems for diagnostic and monitoring purposes. Microneedles are manufactured using a variety of additive and subtractive micromanufacturing techniques. In the last decade, much attention has been paid to using additive manufacturing techniques in both research and industry, such as 3D printing, fused deposition modeling, inkjet printing, and two-photon polymerization (2PP), with 2PP being the most flexible method for the fabrication of microneedle arrays. 2PP is one of the most versatile and precise additive manufacturing processes, which enables the fabrication of arbitrary three-dimensional (3D) prototypes directly from computer-aided-design (CAD) models with a resolution down to 100 nm. Due to its unprecedented flexibility and high spatial resolution, the use of this technology has been widespread for the fabrication of bio-microdevices and bio-nanodevices such as microneedles and microfluidic devices. This is a pioneering transformative technology that facilitates the fabrication of complex miniaturized structures that cannot be fabricated with established multistep manufacturing methods such as injection molding, photolithography, and etching. Thus, microstructures are designed according to structural and fluid dynamics considerations rather than the manufacturing constraints imposed by methods such as machining or etching processes. This article presents the fundamentals of 2PP and the recent development of microneedle array fabrication through 2PP as a precise and unique method for the manufacture of microstructures, which may overcome the shortcomings of conventional manufacturing processes.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Mechanical and Electrical Engineering (1 Jul 2013 - 31 Dec 2021)
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Mechanical and Electrical Engineering (1 Jul 2013 - 31 Dec 2021)
Date Deposited: 02 Mar 2022 02:57
Last Modified: 17 Mar 2022 03:32
Uncontrolled Keywords: Additive manufacturing process; Computer aided design models; Conventional manufacturing; High spatial resolution; Manufacturing constraint; Manufacturing techniques; Micromanufacturing techniques; Two photon polymerization
Fields of Research (2020): 40 ENGINEERING > 4014 Manufacturing engineering > 401401 Additive manufacturing
40 ENGINEERING > 4003 Biomedical engineering > 400303 Biomechanical engineering
40 ENGINEERING > 4003 Biomedical engineering > 400308 Medical devices
Identification Number or DOI: https://doi.org/10.1038/s41378-021-00298-3
URI: http://eprints.usq.edu.au/id/eprint/47110

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