Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

Ebrahiminejad, Vahid and Prewett, Philip D. and Davies, Graham J. and Faraji Rad, Zahra ORCID: https://orcid.org/0000-0001-6528-5965 (2022) Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration. Advanced Materials Interfaces, 9 (6):2101856. pp. 1-26.


Abstract

In the past two decades, microneedles have been extensively studied for transdermal delivery of drug or vaccines and for bio-fluid extraction. Microneedle-based devices consist of micron-size needles that are arranged on a small patch. Despite ongoing advances in microneedle technology, one of the major problems associated with transdermal delivery or sampling is that many of the microneedle patches are not able to fully penetrate the skin surface and reach the epidermis layer of skin. In this regard, for an optimal and effective penetration—painless and safe—it is crucial to consider complex skin mechanics and how it impacts microneedle design and insertion practice. Various types of skin modelling and insertion simulations are considered, followed by discussion of ways of improving microneedle robustness, reduction of insertion force, and enhancement of penetration efficiency.


Statistics for USQ ePrint 46963
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Current – Faculty of Health, Engineering and Sciences - School of Engineering (1 Jan 2022 -)
Faculty/School / Institute/Centre: Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -)
Date Deposited: 17 Mar 2022 03:32
Last Modified: 04 Apr 2022 07:41
Uncontrolled Keywords: drug delivery; microneedle insertion forces; microneedles; penetration efficiency of microneedle arrays into skin; point-of-care diagnostics; skin mechanics
Fields of Research (2008): 09 Engineering > 0913 Mechanical Engineering > 091306 Microelectromechanical Systems (MEMS)
09 Engineering > 0903 Biomedical Engineering > 090302 Biomechanical Engineering
09 Engineering > 0903 Biomedical Engineering > 090301 Biomaterials
09 Engineering > 0913 Mechanical Engineering > 091308 Solid Mechanics
Fields of Research (2020): 40 ENGINEERING > 4017 Mechanical engineering > 401707 Solid mechanics
40 ENGINEERING > 4017 Mechanical engineering > 401705 Microelectromechanical systems (MEMS)
40 ENGINEERING > 4003 Biomedical engineering > 400303 Biomechanical engineering
40 ENGINEERING > 4003 Biomedical engineering > 400302 Biomaterials
Identification Number or DOI: https://doi.org/10.1002/admi.202101856
URI: http://eprints.usq.edu.au/id/eprint/46963

Actions (login required)

View Item Archive Repository Staff Only