High-fidelity replication of thermoplastic microneedles with open microfluidic channels

Faraji Rad, Zahra ORCID: https://orcid.org/0000-0001-6528-5965 and Nordon, Robert E. and Anthony, Carl J. and Bilston, Lynne and Prewett, Philip D. and Arns, Ji-Youn and Arns, Christoph H. and Zhang, Liangchi and Davies, Graham J. (2017) High-fidelity replication of thermoplastic microneedles with open microfluidic channels. Microsystems and Nanoengineering, 3:17034. pp. 1-11.

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Abstract

Development of microneedles for unskilled and painless collection of blood or drug delivery addresses the quality of healthcare through early intervention at point-of-care. Microneedles with submicron to millimeter features have been fabricated from materials such as metals, silicon, and polymers by subtractive machining or etching. However, to date, large-scale manufacture of hollow microneedles has been limited by the cost and complexity of microfabrication techniques. This paper reports a novel manufacturing method that may overcome the complexity of hollow microneedle fabrication. Prototype microneedles with open microfluidic channels are fabricated by laser stereolithography. Thermoplastic replicas are manufactured from these templates by soft-embossing with high fidelity at submicron resolution. The manufacturing advantages are (a) direct printing from computer-aided design (CAD) drawing without the constraints imposed by subtractive machining or etching processes, (b) high-fidelity replication of prototype geometries with multiple reuses of elastomeric molds, (c) shorter manufacturing time compared to three-dimensional stereolithography, and (d) integration of microneedles with open-channel microfluidics. Future work will address development of open-channel microfluidics for drug delivery, fluid sampling and analysis.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 01 Feb 2022 02:26
Last Modified: 02 Feb 2022 05:04
Uncontrolled Keywords: Drug delivery; Laser lithography; Microneedles; Point-of-care diagnostics; Soft embossing
Fields of Research (2008): 09 Engineering > 0903 Biomedical Engineering > 090304 Medical Devices
09 Engineering > 0903 Biomedical Engineering > 090302 Biomechanical Engineering
09 Engineering > 0903 Biomedical Engineering > 090301 Biomaterials
Fields of Research (2020): 40 ENGINEERING > 4016 Materials engineering > 401609 Polymers and plastics
40 ENGINEERING > 4003 Biomedical engineering > 400303 Biomechanical engineering
40 ENGINEERING > 4003 Biomedical engineering > 400302 Biomaterials
Identification Number or DOI: https://doi.org/10.1038/micronano.2017.34
URI: http://eprints.usq.edu.au/id/eprint/45545

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