Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis

Saha, Sukanta and Lim, Carmen C. W. and Cannon, Danielle L. and Burton, Lucinda and Bremner, Monique and Cosgrove, Peter and Yan, Huo and McGrath, John J. (2020) Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis. Depression and Anxiety, 38 (3). pp. 286-306. ISSN 1091-4269

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There is consistent evidence that mood disorders often co-occur with anxiety disorders, however, the strength of the association of these two broad groups of disorders has been challenging to summarize across different studies. The aim was to conduct a meta-analysis of publications reporting on the pairwise comorbidity between mood and anxiety disorders after sorting into comparable study types. We searched MEDLINE, Embase, CINAHL, Web of Science, and the grey literature for publications between 1980 and 2017 regardless of geographical locations and languages. We meta-analyzed estimates from original articles after sorting by: (a) broad or narrow diagnostic criteria, (b) study time-frame, and (c) estimates with or without covariate adjustments. Over 43 000 unique studies were identified through electronic searches, of which 391 were selected for full-text review. Finally, 171 studies were eligible for inclusion, including 53 articles from additional snowball searching. In general, regardless of variations in diagnosis type, study time-frame, temporal order, or use of adjustments, there was substantial comorbidity between mood and anxiety disorders. Based on the entire 90 separate meta-analyses, the median OR was 6.1 (range 1.5-18.7). Of these estimates, all 90 were above 1, and 87 were significantly greater than 1 (i.e., the 95% confidence intervals did not include 1). Fourteen of the 90 pooled estimates had ORs that were greater than 10. This systematic review found robust and consistent evidence of comorbidity between broadly defined mood and anxiety disorders. Clinicians should be vigilant for the prompt identification and treatment of this common type of comorbidity.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2020 The Authors. Depression and Anxiety Published by Wiley Periodicals LLC
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 12 Jan 2022 01:46
Last Modified: 13 Jan 2022 09:16
Uncontrolled Keywords: agoraphobia, anxiety disorders, bipolar disorder, depression, epidemiology, mood disorder
Fields of Research (2008): 11 Medical and Health Sciences > 1117 Public Health and Health Services > 111706 Epidemiology
11 Medical and Health Sciences > 1117 Public Health and Health Services > 111714 Mental Health
Fields of Research (2020): 42 HEALTH SCIENCES > 4202 Epidemiology > 420299 Epidemiology not elsewhere classified
42 HEALTH SCIENCES > 4203 Health services and systems > 420314 Multimorbidity
Socio-Economic Objectives (2020): 20 HEALTH > 2004 Public health (excl. specific population health) > 200409 Mental health
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