Flynn, Julie M. 
ORCID: https://orcid.org/0000-0003-1512-2089 and Keogh, Samantha and Zhang, Li and Rickard, Claire M.
(2017)
Evaluating methods for effective decontamination of central
venous access devices needleless connectors in adult hospital patients: A pilot randomised control trial protocol.
Vascular Access, 3 (2).
pp. 1-18.
ISSN 2204-9762
Abstract
Background: The importance of decontaminating needleless connectors prior to accessing central venous access devices (CVADs) to prevent CVAD-associated bloodstream infection has been highlighted. However, the optimal decontamination time and solution is still under-evaluated. Aim: This study will compare different decontamination methods of CVAD needleless connectors in adult patients. The aims of this pilot trial are: to assess recruitment feasibility, data collection strategies and proposed methods; and to test the interventions with the control to determine an adequate sample size for a future, larger clinical trial. Design: A single-centre, parallel, pilot randomised control trial (RCT) with a superiority design. Methods: There will be three arms: 70% isopropyl alcohol swab (control);2.0% chlorhexidine gluconate in 70% isopropyl alcohol swab; and a 70%isopropyl alcohol-impregnated cap. The primary outcome of this pilot trial is to assess feasibility for a future, larger clinical trial. The secondary outcome is CVAD-associated bloodstream infection. In total, 120 patients will be recruited over six months with a four-week follow-up. Prospective patients who are scheduled to have a CVAD inserted will be eligible. Randomisation will be computer-generated, central and concealed until allocation. Due to the nature of the interventions it will not be possible to blind clinicians or patients. Discussion: Preventing CVAD-associated bloodstream infection in hospitalised patients is vital. Interventional decontamination techniques that demonstrate superior performance in preventing CVAD-associated bloodstream infection would improve patient outcomes, reduce patient morbidity and mortality, and health care-associated costs.
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| Item Type: | Article (Commonwealth Reporting Category C) |
|---|---|
| Refereed: | Yes |
| Item Status: | Live Archive |
| Faculty/School / Institute/Centre: | No Faculty |
| Faculty/School / Institute/Centre: | No Faculty |
| Date Deposited: | 15 Dec 2021 03:32 |
| Last Modified: | 22 Dec 2021 03:29 |
| Uncontrolled Keywords: | Bloodstream infection; CABSI; central venous access device; CVAD; needleless connectors; nursing |
| Fields of Research (2008): | 11 Medical and Health Sciences > 1110 Nursing > 111003 Clinical Nursing: Secondary (Acute Care) 11 Medical and Health Sciences > 1110 Nursing > 111099 Nursing not elsewhere classified |
| Fields of Research (2020): | 42 HEALTH SCIENCES > 4205 Nursing > 420506 Sub-acute care 42 HEALTH SCIENCES > 4205 Nursing > 420501 Acute care 42 HEALTH SCIENCES > 4205 Nursing > 420599 Nursing not elsewhere classified |
| Identification Number or DOI: | https://doi.org/10.3316/informit.632663924727375 |
| URI: | http://eprints.usq.edu.au/id/eprint/44663 |
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