Whole blood viscosity is associated with baseline cerebral perfusion in acute ischemic stroke

Gyawali, Prajwal ORCID: https://orcid.org/0000-0003-0975-5576 and Lillicrap, Thomas Patrick and Tomari, Shinya and Bivard, Andrew and Holliday, Elizabeth and Parsons, Mark and Levi, Christopher and Garcia-Esperon, Carlos and Spratt, Neil (2022) Whole blood viscosity is associated with baseline cerebral perfusion in acute ischemic stroke. Neurological Sciences, 43 (4). pp. 2375-2381. ISSN 1590-1874

[img]
Preview
Text (Published Version)
Gyawali2022_Article_WholeBloodViscosityIsAssociate.pdf
Available under License Creative Commons Attribution 4.0.

Download (635kB) | Preview

Abstract

Whole blood viscosity (WBV) is the intrinsic resistance to flow developed due to the frictional force between adjacent layers of flowing blood. Elevated WBV is an independent risk factor for stroke. Poor microcirculation due to elevated WBV can prevent adequate perfusion of the brain and might act as an important secondary factor for hypoperfusion in acute ischaemic stroke. In the present study, we examined the association of WBV with basal cerebral perfusion assessed by CT perfusion in acute ischaemic stroke. Confirmed acute ischemic stroke patients (n = 82) presenting in hours were recruited from the single centre. Patients underwent baseline multimodal CT (non-contrast CT, CT angiography and CT perfusion). Where clinically warranted, patients also underwent follow-up DWI. WBV was measured in duplicate within 2 h after sampling from 5-mL EDTA blood sample. WBV was significantly correlated with CT perfusion parameters such as perfusion lesion volume, ischemic core volume and mismatch ratio; DWI volume and baseline NIHSS. In a multivariate linear regression model, WBV significantly predicted acute perfusion lesion volume, core volume and mismatch ratio after adjusting for the effect of occlusion site and collateral status. Association of WBV with hypoperfusion (increased perfusion lesion volume, ischaemic core volume and mismatch ratio) suggest the role of erythrocyte rheology in cerebral haemodynamic of acute ischemic stroke. The present findings open new possibilities for therapeutic strategies targeting erythrocyte rheology to improve cerebral microcirculation in stroke.


Statistics for USQ ePrint 43971
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Current – Faculty of Health, Engineering and Sciences - School of Health and Medical Sciences (1 Jan 2022 -)
Faculty/School / Institute/Centre: Current – Faculty of Health, Engineering and Sciences - School of Health and Medical Sciences (1 Jan 2022 -)
Date Deposited: 27 Oct 2021 06:43
Last Modified: 20 Sep 2022 04:18
Uncontrolled Keywords: whole blood viscosity, stroke, CT Perfusion
Fields of Research (2008): 11 Medical and Health Sciences > 1109 Neurosciences > 110904 Neurology and Neuromuscular Diseases
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320905 Neurology and neuromuscular diseases
Socio-Economic Objectives (2008): C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders
Socio-Economic Objectives (2020): 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions
Identification Number or DOI: https://doi.org/10.1007/s10072-021-05666-5
URI: http://eprints.usq.edu.au/id/eprint/43971

Actions (login required)

View Item Archive Repository Staff Only