microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors

Hagstrom, Amanda D. and Denham, Joshua ORCID: https://orcid.org/0000-0001-5804-4960 (2018) microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors. International Journal of Sports Medicine, 39 (6). pp. 482-489. ISSN 0172-4622


Accounting for one in three cancer diagnoses, breast cancer is the second most commonly diagnosed cancer in women. Exercise has a well-accepted role in the multi-disciplinary approach to rehabilitating breast cancer survivors. Despite the many known benefits of resistance training on women recovering from breast cancer, the molecular mechanisms are poorly understood. MicroRNAs are small non-coding RNAs that have crucial roles in growth and development. Here, we analysed the abundance of 9 miRNAs, with known roles in muscle physiology and some linked to cancer, in serum samples from 24 breast cancer survivors before and after a 16-week resistance training or usual care intervention. The resistance training group completed supervised thrice-weekly training. miRNA abundance was assessed before and after the intervention period using qPCR. There were no statistically significant changes in any of the miRNAs between groups after the intervention period (all p>0.05). After assessing miRNA abundance in context with high and low responders to resistance training, we observed that relative to low responders, high responders exhibited increased miR-133a-3p and a borderline statistically significant increase in miR-370-3p. Findings from our controlled study indicate the diverse interindividual miRNA responses to resistance training and reveal a discordant regulation between high and low responders.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 14 Dec 2021 04:31
Last Modified: 15 Dec 2021 03:06
Uncontrolled Keywords: exercise; miRNA; miRNA-133a; muscle strength; small non-coding RNA
Fields of Research (2008): 06 Biological Sciences > 0604 Genetics > 060499 Genetics not elsewhere classified
11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology
Fields of Research (2020): 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310599 Genetics not elsewhere classified
42 HEALTH SCIENCES > 4207 Sports science and exercise > 420702 Exercise physiology
Identification Number or DOI: https://doi.org/10.1055/a-0592-7691
URI: http://eprints.usq.edu.au/id/eprint/43625

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