Age-associated telomere shortening in Thoroughbred horses

Denham, Joshua ORCID: https://orcid.org/0000-0001-5804-4960 and Stevenson, Kim and Denham, Michele M. (2019) Age-associated telomere shortening in Thoroughbred horses. Experimental Gerontology, 127:110718. pp. 1-3. ISSN 0531-5565


Abstract

Telomeres are genetically conserved repetitive terminal DNA that protect against genomic instability and shorten with ageing. Here, we reveal the leukocyte telomere length of Equus caballus by measuring terminal restriction fragments (TRFs) using Southern Blot analysis in a cohort of 43 Thoroughbred horses (age: 24 h–25 years). Heterogeneous TRFs were observed in each animal and large inter-animal variation in mean TRF was observed (range: 10.5–18.7 kbp). Mean TRFs were inversely correlated with age (r = −0.47). The estimated yearly rate of telomere attrition was 134 bp. Horses should be considered as an alternative animal model to investigate environmental and lifestyle factors that regulate telomeres and promote healthy ageing.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 13 Dec 2021 04:55
Last Modified: 15 Dec 2021 03:27
Uncontrolled Keywords: Ageing; Biological ageing; Equus caballus; Racehorse; Telomeres
Fields of Research (2008): 06 Biological Sciences > 0604 Genetics > 060499 Genetics not elsewhere classified
07 Agricultural and Veterinary Sciences > 0707 Veterinary Sciences > 070799 Veterinary Sciences not elsewhere classified
Fields of Research (2020): 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310599 Genetics not elsewhere classified
42 HEALTH SCIENCES > 4207 Sports science and exercise > 420702 Exercise physiology
Identification Number or DOI: https://doi.org/10.1016/j.exger.2019.110718
URI: http://eprints.usq.edu.au/id/eprint/43620

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