Objectively-measured activity patterns are associated with home blood pressure in memory clinic patients

Maasakkers, Carlijn M. and de Heus, Rianne A. A. and Thijssen, Dick H. J. and Melis, Rene J. F. and Gardiner, Paul A. ORCID: https://orcid.org/0000-0002-8072-2673 and Claassen, Jurgen A. H. R. (2020) Objectively-measured activity patterns are associated with home blood pressure in memory clinic patients. Journal of Alzheimer's Disease, 74 (2). pp. 691-697. ISSN 1387-2877

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Abstract

Background: Physicians are cautious to prescribe antihypertensive drugs in frail older adults because of the potential adverse effects, especially in those with cognitive complaints. Lifestyle aspects might provide safe targets to lower blood pressure in older adults.

Objective: Our goal was to evaluate the associations between activity patterns and blood pressure in memory clinic patients.

Methods: We used an observational cross-sectional study to measure activity patterns with the ActivPAL accelerometer, and simultaneous home blood pressure levels in memory clinic patients (age range 51-87 years old). Office blood pressure was assessed during routine clinical practice.

Results: 41 patients (mean age of 74.3 (7.7) years of age, 46% female) were included. Sedentary parameters were associated with higher mean home blood pressure, with the strongest correlation between more prolonged sitting bouts and higher SBP (r = 0.58, p < .0001). Physical activity parameters were negatively associated with mean home blood pressure. Adjusted regression estimates remained significant, showing, e.g., a 4.5 (95% CI = 1.6;7.4) mmHg increase in SBP for every hour of sitting per day and a -1.0 (95% CI = -1.8;-0.2) mmHg decrease in DBP for every additional 1000 steps per day. No strong correlations were found between any of the activity pattern variables and office blood pressure.

Conclusion: Associations between activity pattern variables and blood pressure were only found with home blood pressure measurements, not with office measurements. Longitudinal evaluations of these associations are now needed to explore if reducing prolonged sedentary bouts and increasing step count indeed serve as safe targets to lower blood pressure. © 2020 - IOS Press and the authors. All rights reserved.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 12 Oct 2021 07:17
Last Modified: 20 Oct 2021 03:50
Uncontrolled Keywords: blood pressure; cognitive decline; dementia; hypertension; physical activity; sedentary behavior
Fields of Research (2008): 11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110699 Human Movement and Sports Science not elsewhere classified
17 Psychology and Cognitive Sciences > 1702 Cognitive Sciences > 170299 Cognitive Science not elsewhere classified
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases)
42 HEALTH SCIENCES > 4207 Sports science and exercise > 420799 Sports science and exercise not elsewhere classified
52 PSYCHOLOGY > 5204 Cognitive and computational psychology > 520401 Cognition
Identification Number or DOI: https://doi.org/10.3233/JAD-191310
URI: http://eprints.usq.edu.au/id/eprint/43580

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