The association of sedentary behaviour and cognitive function in people without dementia: A coordinated analysis across five cohort studies from COSMIC

Maasakkers, Carlijn M. and Claassen, Jurgen A. H. R. and Gardiner, Paul A. ORCID: https://orcid.org/0000-0002-8072-2673 and Olde Rikkert, Marcel G. M. and Lipnicki, Darren M. and Scarmeas, Nikolaos and Dardiotis, Efthimios and Yannakoulia, Mary and Anstey, Kaarin J. A. and Cherbuin, Nicolas and Haan, Mary N. and Kumagai, Shuzo and Narazaki, Kenji and Chen, Tao and Ng, Tze Pin and Gao, Qi and Nyunt, Ma S. Z. and Crawford, John D. and Kochan, Nicole A. and Makkar, Steve R. and Sachdev, Perminder S. and COSMIC Collaborators, . and Thijssen, Dick H. J. and Melis, Rene J. F. (2020) The association of sedentary behaviour and cognitive function in people without dementia: A coordinated analysis across five cohort studies from COSMIC. Sports Medicine, 50 (2). pp. 403-413. ISSN 0112-1642

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Abstract

Background
Besides physical activity as a target for dementia prevention, sedentary behaviour is hypothesized to be a potential target in its own right. The rising number of persons with dementia and lack of any effective treatment highlight the urgency to better understand these modifiable risk factors. Therefore, we aimed to investigate whether higher levels of sedentary behaviour are associated with reduced global cognitive functioning and slower cognitive decline in older persons without dementia.

Methods
We used five population cohorts from Greece, Australia, USA, Japan, and Singapore (HELIAD, PATH, SALSA, SGS, and SLAS2) from the Cohort Studies of Memory in an International Consortium. In a coordinated analysis, we assessed the relationship between sedentary behaviour and global cognitive function with the use of linear mixed growth model analysis (mean follow-up range of 2.0–8.1 years).

Results
Baseline datasets combined 10,450 older adults without dementia with a mean age range between cohorts of 66.7–75.1 years. After adjusting for multiple covariates, no cross-sectional association between sedentary behaviour and cognition was found in four studies. One association was detected where more sedentary behaviour was cross-sectionally linked to higher cognition levels (SLAS2, B = 0.118 (0.075; 0.160), P < 0.001). Longitudinally, there were no associations between baseline sedentary behaviour and cognitive decline (P > 0.05).

Conclusions
Overall, these results do not suggest an association between total sedentary time and lower global cognition in older persons without dementia at baseline or over time. We hypothesize that specific types of sedentary behaviour may differentially influence cognition which should be investigated further. For now, it is, however, too early to establish undifferentiated sedentary time as a potential effective target for minimizing cognitive decline in older adults without dementia.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 06 Oct 2021 02:31
Last Modified: 20 Oct 2021 03:49
Uncontrolled Keywords: Aged; Cognition; Cognitive Dysfunction; Cohort Studies; Dementia; Female; Humans; Male; Sedentary Behavior; Surveys and Questionnaires
Fields of Research (2008): 11 Medical and Health Sciences > 1117 Public Health and Health Services > 111706 Epidemiology
11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110699 Human Movement and Sports Science not elsewhere classified
17 Psychology and Cognitive Sciences > 1702 Cognitive Sciences > 170299 Cognitive Science not elsewhere classified
Fields of Research (2020): 42 HEALTH SCIENCES > 4202 Epidemiology > 420201 Behavioural epidemiology
42 HEALTH SCIENCES > 4207 Sports science and exercise > 420799 Sports science and exercise not elsewhere classified
52 PSYCHOLOGY > 5204 Cognitive and computational psychology > 520401 Cognition
Identification Number or DOI: https://doi.org/10.1007/s40279-019-01186-7
URI: http://eprints.usq.edu.au/id/eprint/43579

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