Biomarkers of the health outcomes associated with ambient particulate matter exposure

Yang, Lixin and Hou, Xiang-Yu and Wei, Yongjie and Thai, Phong and Chai, Fahe (2017) Biomarkers of the health outcomes associated with ambient particulate matter exposure. Science of the Total Environment, 579. pp. 1446-1459. ISSN 0048-9697


Epidemiologic evidence support the positive association of cardiopulmonary morbidity and mortality, and lung cancer risk with exposure to airborne particulate matter (PM). Oxidative stress and inflammation have been proposed to be the major causal factors involved in mediating PM effects on both cardiovascular and pulmonary health outcomes. However, the mechanism whereby PM causes the health effects is not fully elucidated. To evaluate and investigate human exposure to PM, it is essential to have a specific, sensitive and robust characterization of individual exposure to PM. Biomarkers may mark important intermediate steps leading to overt health effects after PM exposure. Thus biomarkers are promising indicators, which could serve as representative measures of the exposure to PM for assessing the health impacts and understanding the mechanism. Indeed, a number of biomarkers are already in use in the field of epidemiological studies and toxicological research. However, we are facing now the challenges to select robust, specific and sensitive biomarkers, which can be employed in large-scale of population to assess the health risk and to monitor the effectiveness of interventions. In this review, we describe a range of biomarkers that are associated with air pollution exposure, particularly markers of oxidative stress, inflammatory factors, and microRNAs, as well as markers of pollutants metabolites. Understanding the nature of the association of these biomarkers with PM exposure may shed some light on the process of selecting biomarkers for large-scale population studies, developing novel preventative and therapeutic strategies.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 17 Jun 2021 05:44
Last Modified: 31 Aug 2021 03:29
Uncontrolled Keywords: Air quality, Biomarker, Health outcome
Fields of Research (2008): 05 Environmental Sciences > 0502 Environmental Science and Management > 050204 Environmental Impact Assessment
05 Environmental Sciences > 0502 Environmental Science and Management > 050205 Environmental Management
05 Environmental Sciences > 0502 Environmental Science and Management > 050206 Environmental Monitoring
Fields of Research (2020): 41 ENVIRONMENTAL SCIENCES > 4104 Environmental management > 410404 Environmental management
41 ENVIRONMENTAL SCIENCES > 4105 Pollution and contamination > 410599 Pollution and contamination not elsewhere classified
42 HEALTH SCIENCES > 4206 Public health > 420605 Preventative health care
Socio-Economic Objectives (2008): D Environment > 96 Environment > 9601 Air Quality > 960106 Urban and Industrial Air Quality
C Society > 92 Health > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine
Socio-Economic Objectives (2020): 20 HEALTH > 2004 Public health (excl. specific population health) > 200412 Preventive medicine
18 ENVIRONMENTAL MANAGEMENT > 1801 Air quality, atmosphere and weather > 180101 Air quality
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