Serum levels of androgens in acne & their role in acne severity

Iftikhar, Usma ORCID: https://orcid.org/0000-0002-2400-0799 and Choudhry, Nakshab (2019) Serum levels of androgens in acne & their role in acne severity. Pakistan Journal of Medical Sciences, 35 (1). pp. 146-150. ISSN 1682-024X

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Abstract

Objectives: To correlate acne severity with elevated androgen levels and to compare androgen levels between cases and controls.

Methods: This case-control study was carried out in the Department of Dermatology, Mayo Hospital, Lahore from March 2016 – March 2017. Two hundred and seventy patients and eighty age and gender-matched controls were recruited after ethical approval and informed consent and categorized into mild, moderate and severe acne. Severity was correlated with serum Testosterone, Dihydrotestoststerone and Dihydroepiandrosterone Sulphate levels. Quantitative variables were expressed as median and percentiles, comparisons done by Mann-Whitney and correlations by Spearman correlation. P-value of <0.05 was considered statistically significant.

Results: There were 142 (41%) males and 208 (59%) females. Ninety-Seven patients had mild, 108 moderate and 65 had severe disease. Median hormonal levels were 3.5ng/ml, 184pg/ml and 0.82ug/dl for Testosterone, Dihydrotestosterone and Dihydroepiandrosterone Sulphate respectively which differed significantly between cases and controls. There was no correlation with severity but the levels differed significantly between the different grades in case of Testosterone and DHEAS.

Conclusion: Androgens are not directly correlated with acne severity, but affect acne severity as seen in difference between their levels in different grades of acne. Anti-androgens may be initiated early in acne resistant to conventional therapy.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 08 Jan 2021 03:31
Last Modified: 01 Feb 2021 01:07
Uncontrolled Keywords: Acne vulgaris, Androgens, Hyperandrogenism, Acne Severity
Fields of Research (2008): 11 Medical and Health Sciences > 1103 Clinical Sciences > 110304 Dermatology
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320599 Medical biochemistry and metabolomics not elsewhere classified
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Socio-Economic Objectives (2020): 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions
Identification Number or DOI: doi:10.12669/pjms.35.1.131
URI: http://eprints.usq.edu.au/id/eprint/40486

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