Rheumatic heart disease: A review of the current status of global research activity

Dooley, Leanne M. and Ahmad, Tarek B. and Pandey, Manisha and Good, Micheal F. and Kotiw, Michael (2020) Rheumatic heart disease: A review of the current status of global research activity. Autoimmunity Reviews:102740. pp. 1-80. ISSN 1568-9972


Abstract

Rheumatic heart disease (RHD) is a serious and long-term consequence of acute rheumatic fever (ARF), an autoimmune sequela of a mucosal infection by Streptococcus pyogenes (Group A Streptococcus, Strep A). The pathogenesis of ARF and RHD is complex and not fully understood but involves host and bacterial factors, molecular mimicry, and aberrant host innate and adaptive immune responses that result in loss of self-tolerance and subsequent cross-reactivity with host tissues. RHD is entirely preventable yet claims an estimated 320 000 lives annually. The major burden of disease is carried by developing nations and Indigenous populations within developed nations, including Australia. This review will focus on the epidemiology, pathogenesis and treatment of ARF and RHD in Australia, where: streptococcal pyoderma, rather than streptococcal pharyngitis, and Group C and Group G Streptococcus, have been implicated as antecedents to ARF; the rates of RHD in remote Indigenous communities are persistently among the highest in the world; government register-based programs coordinate disease screening and delivery of prophylaxis with variable success; and researchers are making significant progress in the development of a broad-spectrum vaccine against Strep A.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 -)
Faculty/School / Institute/Centre: Current - Institute for Resilient Regions - Centre for Health Research (1 Apr 2020 -)
Date Deposited: 07 Jan 2021 23:17
Last Modified: 19 Jan 2021 05:02
Uncontrolled Keywords: Rheumatic fever; Rheumatic heart disease; Group A Streptococcus; M protein; Australian Aboriginal Vaccine
Fields of Research (2008): 11 Medical and Health Sciences > 1107 Immunology > 110703 Autoimmunity
11 Medical and Health Sciences > 1117 Public Health and Health Services > 111701 Aboriginal and Torres Strait Islander Health
11 Medical and Health Sciences > 1117 Public Health and Health Services > 111704 Community Child Health
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320403 Autoimmunity
45 INDIGENOUS STUDIES > 4504 Aboriginal and Torres Strait Islander health and wellbeing > 450403 Aboriginal and Torres Strait Islander child health and wellbeing
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases
Socio-Economic Objectives (2008): C Society > 92 Health > 9203 Indigenous Health > 920302 Aboriginal and Torres Strait Islander Health - Health Status and Outcomes
C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases
Socio-Economic Objectives (2020): 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions
21 INDIGENOUS > 2103 Aboriginal and Torres Strait Islander health > 210301 Aboriginal and Torres Strait Islander determinants of health
20 HEALTH > 2003 Provision of health and support services > 200303 Health surveillance
Identification Number or DOI: https://doi.org/10.1016/j.autrev.2020.102740
URI: http://eprints.usq.edu.au/id/eprint/40430

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