Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study

Rose, Stephen E. and Chalk, Jonathan B. and Janke, Andrew L. and Strudwick, Mark W. and Windus, Louisa C. ORCID: https://orcid.org/0000-0002-7186-459X and Hannah, Dominique E. and McGrath, John J. and Pantelis, Christos and Wood, Stephen J. and Mowry, Bryan J. (2006) Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study. NeuroImage, 32 (1). pp. 16-22. ISSN 1053-8119


Abstract

MRI diffusion tensor imaging (DTI), optimized for measuring the trace of the diffusion tensor, was used to investigate microstructural changes in the brains of 12 individuals with schizophrenia compared with 12 matched control subjects. To control for the effects of anatomic variation between subject groups, all participants' diffusion images were nonlinearly registered to standard anatomical space. Significant statistical differences in mean diffusivity (MD) measures between the two groups were determined on a pixel-by-pixel basis, using Gaussian random field theory. We found significantly elevated MD measures within temporal, parietal and prefrontal cortical regions in the schizophrenia group (P > 0.001), especially within the medial frontal gyrus and anterior cingulate. The dorsal medial and anterior nucleus of the thalamus, including the caudate, also exhibited significantly increased MD in the schizophrenia group (P > 0.001). This study has shown for the first time that MD measures offer an alternative strategy for investigating altered prefrontal–thalamic circuitry in schizophrenia.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 27 Oct 2020 04:58
Last Modified: 27 Oct 2020 05:08
Uncontrolled Keywords: Schizophrenia; Diffusion MRI; Thalamus; Anterior cingulate
Fields of Research (2008): 06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060199 Biochemistry and Cell Biology not elsewhere classified
Fields of Research (2020): 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310199 Biochemistry and cell biology not elsewhere classified
Funding Details:
Identification Number or DOI: https://doi.org/10.1016/j.neuroimage.2006.03.003
URI: http://eprints.usq.edu.au/id/eprint/39997

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