Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions

Windus, Louisa C. E. ORCID: https://orcid.org/0000-0002-7186-459X and Lineburg, Katie E. and Scott, Susan E. and Claxton, Christina and Mackay-Sim, Alan and Key, Brian and St John, James A. (2010) Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions. Cellular and Molecular Life Sciences, 67 (10). pp. 1735-1750. ISSN 1420-682X

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Abstract

The growth and guidance of primary olfactory axons are partly attributed to the presence of olfactory ensheathing cells (OECs). However, little is understood about the differences between the subpopulations of OECs and what regulates their interactions. We used OEC-axon assays and determined that axons respond differently to peripheral and central OECs. We then further purified OECs from anatomically distinct regions of the olfactory bulb. Cell behaviour assays revealed that OECs from the olfactory bulb were a functionally heterogeneous population with distinct differences which is consistent with their proposed roles in vivo. We found that the heterogeneity was regulated by motile lamellipodial waves along the shaft of the OECs and that inhibition of lamellipodial wave activity via Mek1 abolished the ability of the cells to distinguish between each other. These results demonstrate that OECs from the olfactory bulb are a heterogeneous population that use lamellipodial waves to regulate cell–cell recognition.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 26 Oct 2020 23:43
Last Modified: 27 Oct 2020 05:27
Uncontrolled Keywords: Olfactory bulb; Axon; Regeneration; Glia; Mek1
Fields of Research (2008): 06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060106 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060103 Cell Development, Proliferation and Death
Fields of Research (2020): 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310105 Cellular interactions (incl. adhesion, matrix, cell wall)
31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310102 Cell development, proliferation and death
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
Funding Details:
Identification Number or DOI: https://doi.org/10.1007/s00018-010-0280-3
URI: http://eprints.usq.edu.au/id/eprint/39985

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