Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications

Wang, Song and Duan, Chunyan and Yang, Weizhong and Gao, Xiangyu and Shi, Jiacheng and Kang, Jianping and Deng, Yi and Shi, Xiao-Lei ORCID: https://orcid.org/0000-0003-0905-2547 and Chen, Zhi-Gang ORCID: https://orcid.org/0000-0002-9309-7993 (2020) Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications. Nanoscale, 12 (22). pp. 11936-11946. ISSN 2040-3364


Abstract

As one of the promising orthopedic materials, polyetheretherketone (PEEK) has high chemical durability and similar mechanical properties to the cortical bone; nevertheless, the inherent bioinert nature of PEEK dramatically impedes its broader clinical applications in the management of bone infection. To address this challenge, herein, we developed a multifunctional two-dimensional (2D) nanocoating to assemble graphene oxide (GO) nanosheets, a polydopamine (pDA) nanofilm, and an oligopeptide onto the surface of porous sulfonated PEEK (SPEEK). The resulting multifunctional PEEK implants exhibited enhanced cytocompatibility, alkaline phosphatase activity, and calcium matrix deposition as well as osteogenesis-associated gene expression. Moreover, the animal experiments based on a rabbit femur defect model confirmed that the 2D nanocoating prominently boosted the in vivo osseointegration and bone remodeling. Besides, the GO/pDA hybrid complex anchoring on the SPEEK surface through π–π stacking can generate robust antibacterial phototherapy resulting from the synergetic photothermal/photodynamic therapeutic effects. Accordingly, this work provides a paradigm to empower inert PEEK implants with bi-/multi-modal therapeutic applications, such as against bone infection treatment.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -)
Faculty/School / Institute/Centre: Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -)
Date Deposited: 23 Jul 2020 02:55
Last Modified: 27 Jul 2020 03:26
Uncontrolled Keywords: Graphene oxide; antimicrobial peptides; bone; silver; agent; osseointegration; differentiation; nanoparticles; architectures; osteogenesis
Fields of Research (2008): 09 Engineering > 0912 Materials Engineering > 091205 Functional Materials
Identification Number or DOI: https://doi.org/10.1039/d0nr02327b
URI: http://eprints.usq.edu.au/id/eprint/38888

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