A systematic review on the Sambuci fructus effect and efficacy profiles

Vlachojannis, J. E. and Cameron, M. ORCID: https://orcid.org/0000-0001-5788-8790 and Chrubasik, S. (2010) A systematic review on the Sambuci fructus effect and efficacy profiles. Phytotherapy Research, 24 (1). pp. 1-8. ISSN 0951-418X


Abstract

The berries of European elder are used in traditional German medicine for various complaints. Due to insufficient research data, elderberry fruit was not monographed by the German Commission E at the end of the last century. A comprehensive review of the literature was conducted to summarize the pharmacological and clinical effects of elderberry fruit. Several databases and other sources were searched to identify in vitro and animal studies, and clinical trials investigating elderberry fruit preparations. For the latter, the level of evidence was evaluated as described previously. Elderberry fruit preparations may provide antioxidant, antiviral and antiproliferative effects in vitro. One animal experiment and one clinical trial were able to back the antioxidative impact in terms of a weak antilipidemic effect. Antibacterial and antiinflammatory effects seem possible, but need further support. In rats, an aqueous elderberry fruit extract produced central depression and analgesia and an ethanol fruit extract improved acetic acid-induced colitis. Several in vitro studies together with two exploratory studies in humans and one open study in chimpanzees indicate that the aqueous elderberry extract Sambucol may be useful for the treatment of viral influenza infections. These promising effects of elderberry fruit preparations from experimental and clinical studies should be backed by more rigorous studies before these preparations are recommended in the prevention of diseases and in treatment schedules.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version, in accordance with the copyright policy oft eh publisher.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 01 Feb 2021 05:26
Last Modified: 01 Feb 2021 05:26
Uncontrolled Keywords: elderberry; Sambuci fructus; Caprifoliaceae; effects; efficacy
Fields of Research (2008): 11 Medical and Health Sciences > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified
Fields of Research (2020): 42 HEALTH SCIENCES > 4208 Traditional, complementary and integrative medicine > 420899 Traditional, complementary and integrative medicine not elsewhere classified
Socio-Economic Objectives (2008): C Society > 92 Health > 9299 Other Health > 929999 Health not elsewhere classified
Socio-Economic Objectives (2020): 20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified
Identification Number or DOI: https://doi.org/10.1002/ptr.2729
URI: http://eprints.usq.edu.au/id/eprint/38789

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