Graphene Oxide and Adiponectin-Functionalized Sulfonated Polyetheretherketone with Effective Osteogenicity and Remotely Repeatable Photo-Disinfection

Deng, Yi and Gao, Xiangyu and Shi, Xiao-Lei ORCID: https://orcid.org/0000-0003-0905-2547 and Lu, Siyu and Yang, Weizhong and Duan, Chunyan and Chen, Zhi-Gang ORCID: https://orcid.org/0000-0002-9309-7993 (2020) Graphene Oxide and Adiponectin-Functionalized Sulfonated Polyetheretherketone with Effective Osteogenicity and Remotely Repeatable Photo-Disinfection. Chemistry of Materials, 32 (5). pp. 2180-2193. ISSN 0897-4756

[img]
Preview
Text (Accepted Version)
03 - 20200211 - Graphene Oxide and Adiponectin-Functionalized.pdf

Download (2MB) | Preview

Abstract

Biomaterial-associated infection (BAI) is a serious threat to patient health. In general, bacteriostatic agents are loaded on the surface of biomaterials to eliminate BAI; however, the excessive usage of these agents leads to the emergence of drug-resistant bacteria and inadequacy of tissue repair. To address this issue, here, we create a photo-responsive and osteopromotive coating that consists of graphene oxide (GO) nanosheets, polydopamine (pDA) nanolayers, and adiponectin (APN) protein on bioinert sulfonated polyetheretherketone (sPEEK/GO/APN). The functionalized samples display superior cytocompatibility and in viro osteogenicity regarding cell reproduction, spreading, alkaline phosphatase activity, extracellular matrix calcification, and osteo-associated genes expression, outperforming sPEEK/GO and sPEEK/APN samples. The in vivo evaluation using a rabbit femur defect model demonstrates that the multifunctional coating significantly boosts bone regeneration and osseointegration. More importantly, the GO/pDA complex bonded together through π-π stacking and electrostatic interactions gives rise to robust cyclic photothermal bacteria-killing ability towards both Gram-positive and Gram-negative bacteria. Such a surface engineering platform may enable biomedical implants with enhanced osteogenicity ability and remotely recyclable photo-disinfection, holding great potential in the treatment of incurable infective bone loss.


Statistics for USQ ePrint 38021
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -)
Faculty/School / Institute/Centre: Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -)
Date Deposited: 22 Jun 2020 05:28
Last Modified: 10 Feb 2021 22:05
Uncontrolled Keywords: PEEK; graphene oxide; adiponectin; osteogenicity; photo-disinfection
Fields of Research (2008): 09 Engineering > 0912 Materials Engineering > 091205 Functional Materials
Identification Number or DOI: https://doi.org/10.1021/acs.chemmater.0c00290
URI: http://eprints.usq.edu.au/id/eprint/38021

Actions (login required)

View Item Archive Repository Staff Only