Health effects of arsenic exposure in Latin America: An overview of the past eight years of research

Khan, Khalid M. and Chakraborty, Rishika and Bundschuh, Jochen and Bhattacharya, Prosun and Parvez, Faruque (2020) Health effects of arsenic exposure in Latin America: An overview of the past eight years of research. Science of the Total Environment, 710:136071. pp. 1-17. ISSN 0048-9697


Abstract

Studies conducted over the past eight years in Latin America (LA) have continued to produce new knowledge regarding health impacts of arsenic (As) in drinking water. We conducted a systematic review of 92 peer-reviewed English articles published between 2011 and 2018 to expand our understanding on these health effects. Majority of the LA studies on As have been conducted in Chile and Mexico. Additional data have emerged from As-exposed populations in Argentina, Bolivia, Brazil, Colombia, Ecuador, and Uruguay. The present review has documented recent data on the biomarkers of As exposure, genetic susceptibility and genotoxicity, and risk assessment to further characterize the health effects and exposed populations. Some recent findings on the associations of As with bladder and lung cancers, reproductive outcomes, and declined cognitive performance have been consistent with what we reported in our previous systematic review article. We have found highly convincing evidence of in utero As exposure as a significant risk factor for several health outcomes, particularly for bladder cancer, even at moderate level. New data have emerged regarding the associations of As with breast and laryngeal cancers as well as type 2 diabetes. We observed early life As exposure to be associated with kidney injury, carotid intima-media thickness, and various pulmonary outcomes in children. Other childhood effects such as low birth weight, low gestational age, anemia, increased apoptosis, and decreased cognitive functions were also reported. Studies identified genetic variants of As methyltransferase that could determine susceptibility to As related health outcomes. Arsenic-induced DNA damage and alteration of gene and protein expression have also been reported. While the scope of research is still vast, the substantial work done on As exposure and its health effects in LA will help direct further large-scale studies for more comprehensive knowledge and plan appropriate mitigation strategies.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Civil Engineering and Surveying (1 July 2013 -)
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Civil Engineering and Surveying (1 July 2013 -)
Date Deposited: 22 Jun 2020 02:18
Last Modified: 27 Jul 2020 00:34
Uncontrolled Keywords: Water arsenic; Latin America; Cancers; Cardiopulmonary outcomes; In utero and early life effects Genetic susceptibility
Fields of Research (2008): 05 Environmental Sciences > 0502 Environmental Science and Management > 050204 Environmental Impact Assessment
11 Medical and Health Sciences > 1117 Public Health and Health Services > 111705 Environmental and Occupational Health and Safety
Socio-Economic Objectives (2008): D Environment > 96 Environment > 9699 Other Environment > 969999 Environment not elsewhere classified
C Society > 92 Health > 9204 Public Health (excl. Specific Population Health) > 920405 Environmental Health
Identification Number or DOI: 10.1016/j.scitotenv.2019.136071
URI: http://eprints.usq.edu.au/id/eprint/38003

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