Facile synthesis and characterization of multifunctional cobalt-based nanocomposites for targeted chemo-photothermal synergistic cancer therapy

Zhu, Huang and Deng, Jiuhong and Yang, Zhaopu and Deng, Yi and Yang, Weizhong and Shi, Xiao-Lei ORCID: https://orcid.org/0000-0003-0905-2547 and Chen, Zhi-Gang (2019) Facile synthesis and characterization of multifunctional cobalt-based nanocomposites for targeted chemo-photothermal synergistic cancer therapy. Composites Part B: Engineering, 178 (Article 107521). ISSN 1359-8368


Abstract

In this study, we develop polyethylene glycol (PEG) modified nanocomposites, which structurally constitute graphene oxide (GO) and cobalt nanoparticles (CoNPs), called as the CoNPs-GO-PEG nanocomposites. These CoNPs-GO-PEG nanocomposites show better outcomes and less side effects when eliminating tumor cells. After a series of comprehensive characterizations, the CoNPs-GO-PEG nanocomposites are proved to possess pleasing targeting ability and unique drug release behavior, indicating that the concentration of the drug delivered by CoNPs-GO-PEG in the tumor site is much higher than that in the normal tissue, and concerning the favorable biocompatibility of CoNPs-GO-PEG nanocomposites, less harm is caused to normal tissue compared to traditional chemotherapy. Furthermore, because of the satisfactory photothermal effect and favorable drug release behavior of the material, the CoNPs-GO-PEG are able to eradicate most of the tumor cells (99%) through synergistic chemo-photothermal therapy in vitro. So far, our study has demonstrated an inspiring potential for the CoNPs-GO-PEG nanocomposites to act as a favorable targeting multifunctional agent in cancer therapy.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version, in accordance with the copyright policy of the publisher.
Faculty/School / Institute/Centre: Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -)
Faculty/School / Institute/Centre: Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -)
Date Deposited: 06 Mar 2020 05:33
Last Modified: 13 Mar 2020 06:51
Uncontrolled Keywords: metal-matrix composites (MMCs), photothermal, nano-structures, surface properties, magnetic properties
Fields of Research : 09 Engineering > 0912 Materials Engineering > 091205 Functional Materials
Identification Number or DOI: 10.1016/j.compositesb.2019.107521
URI: http://eprints.usq.edu.au/id/eprint/37943

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