Zhu, Huang and Deng, Jiuhong and Yang, Zhaopu and Deng, Yi and Yang, Weizhong and Shi, Xiao-Lei 
ORCID: https://orcid.org/0000-0003-0905-2547 and Chen, Zhi-Gang ORCID: https://orcid.org/0000-0002-9309-7993
(2019)
Facile synthesis and characterization of multifunctional cobalt-based nanocomposites for targeted chemo-photothermal synergistic cancer therapy.
Composites Part B: Engineering, 178 (Article 107521).
ISSN 1359-8368
Abstract
In this study, we develop polyethylene glycol (PEG) modified nanocomposites, which structurally constitute graphene oxide (GO) and cobalt nanoparticles (CoNPs), called as the CoNPs-GO-PEG nanocomposites. These CoNPs-GO-PEG nanocomposites show better outcomes and less side effects when eliminating tumor cells. After a series of comprehensive characterizations, the CoNPs-GO-PEG nanocomposites are proved to possess pleasing targeting ability and unique drug release behavior, indicating that the concentration of the drug delivered by CoNPs-GO-PEG in the tumor site is much higher than that in the normal tissue, and concerning the favorable biocompatibility of CoNPs-GO-PEG nanocomposites, less harm is caused to normal tissue compared to traditional chemotherapy. Furthermore, because of the satisfactory photothermal effect and favorable drug release behavior of the material, the CoNPs-GO-PEG are able to eradicate most of the tumor cells (99%) through synergistic chemo-photothermal therapy in vitro. So far, our study has demonstrated an inspiring potential for the CoNPs-GO-PEG nanocomposites to act as a favorable targeting multifunctional agent in cancer therapy.
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| Item Type: | Article (Commonwealth Reporting Category C) |
|---|---|
| Refereed: | Yes |
| Item Status: | Live Archive |
| Additional Information: | Permanent restricted access to Published version, in accordance with the copyright policy of the publisher. |
| Faculty/School / Institute/Centre: | Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -) |
| Faculty/School / Institute/Centre: | Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -) |
| Date Deposited: | 06 Mar 2020 05:33 |
| Last Modified: | 13 Mar 2020 06:51 |
| Uncontrolled Keywords: | metal-matrix composites (MMCs), photothermal, nano-structures, surface properties, magnetic properties |
| Fields of Research (2008): | 09 Engineering > 0912 Materials Engineering > 091205 Functional Materials |
| Identification Number or DOI: | https://doi.org/10.1016/j.compositesb.2019.107521 |
| URI: | http://eprints.usq.edu.au/id/eprint/37943 |
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