Cholesterol versus inflammation as cause of chronic diseases

Panchal, Sunil K. and Brown, Lindsay (2019) Cholesterol versus inflammation as cause of chronic diseases. Nutrients, 11 (10):2332. pp. 1-7.

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Tsoupras and colleagues have postulated, in a recent review in Nutrients, that the key to reducing the incidence of cardiovascular disease is to control the activities of inflammatory mediators such as platelet-activating factor (PAF) by diet, exercise, and healthy lifestyle choices [1]. We agree with this sensible conclusion, which is based on the extensive scientific literature. The authors argue that their proposal is contrary to the lipid (or cholesterol) hypothesis. This supposes that the reduction of plasma lipid concentrations will reduce new incidents of cardiovascular disease, a concept developed over many decades from the recommendation in 1976 that a combined drug/diet regimen in a study with large numbers of male hyperlipidemic subjects would be necessary to test the accuracy of the hypothesis [2]. Following extensive studies with the statins as lipid-lowering drugs, the accumulation of evidence for the lipid hypothesis was then presented in 2006 with Steinberg concluding that the controversy was solved by the results of these studies, stating that “The cholesterol controversy could have been resolved much earlier if all of us had looked at all of the evidence” [3]. However, this conclusion on the lipid hypothesis continues to arouse passionate arguments, as shown in the review by Tsoupras and colleagues [1] and in other recent reviews [4].

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Historic - Institute for Resilient Regions - Centre for Health, Informatics and Economic Research (1 Aug 2018 - 31 Mar 2020)
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 - 31 Dec 2021)
Date Deposited: 08 Oct 2019 02:00
Last Modified: 07 Jun 2021 00:29
Uncontrolled Keywords: chronic disease; cholesterol; inflammation; diet; statin; cardiovascular
Fields of Research (2008): 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321004 Nutritional science
32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321401 Basic pharmacology
32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases)
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
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