Geographical variations in prostate cancer outcomes: a systematic review of international evidence

Dasgupta, Paramita and Baade, Peter and Aitken, Joanne and Ralph, Nicholas and Chambers, Suzanne Kathleen and Dunn, Jeff (2019) Geographical variations in prostate cancer outcomes: a systematic review of international evidence. Frontiers in Oncology, 9 (238). pp. 1-35.

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Abstract

Background: Previous reviews of geographical disparities in the prostate cancer continuum from diagnosis to mortality have identified a consistent pattern of poorer outcomes with increasing residential disadvantage and for rural residents. However, there are no contemporary, systematic reviews summarizing the latest available evidence. Our objective was to systematically review the published international evidence for geographical variations in prostate cancer indicators by residential rurality and disadvantage.
Methods: Systematic searches of peer-reviewed articles in English published from 1/1/1998 to 30/06/2018 using PubMed, EMBASE, CINAHL, and Informit databases. Inclusion criteria were: population was adult prostate cancer patients; outcome measure was PSA testing, prostate cancer incidence, stage at diagnosis, access to and use of services, survival, and prostate cancer mortality with quantitative results by residential rurality and/or disadvantage. Studies were critically appraised using a modified Newcastle-Ottawa Scale.
Results: Overall 169 studies met the inclusion criteria. Around 50% were assessed as high quality and 50% moderate. Men from disadvantaged areas had consistently lower prostate-specific antigen (PSA) testing and prostate cancer incidence, poorer survival, more advanced disease and a trend toward higher mortality. Although less consistent, predominant patterns by rurality were lower PSA testing, prostate cancer incidence and survival, but higher stage disease and mortality among rural men. Both geographical measures were associated with variations in access and use of prostate cancer-related services for low to high risk disease.
Conclusions: This review found substantial evidence that prostate cancer indicators varied by residential location across diverse populations and geographies. While wide variations in study design limited comparisons across studies, our review indicated that internationally, men living in disadvantaged areas, and to a lesser extent more rural areas, face a greater prostate cancer burden. This review highlights the need for a better understanding of the complex social, environmental, and behavioral reasons for these variations, recognizing that, while important, geographical access is not the only issue. Implementing research strategies to help identify these processes and to better understand the central role of disadvantage to variations in health outcome are crucial to inform the development of evidence-based targeted interventions.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: File associated with this item are made available in accordance with the Creative Commons Attribution License (CC BY).
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Nursing and Midwifery (1 Jan 2015 -)
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Nursing and Midwifery (1 Jan 2015 -)
Date Deposited: 01 Jul 2019 05:24
Last Modified: 04 Jul 2019 00:55
Uncontrolled Keywords: prostate cancer; rural; area-disadvantage; health disparity; systematic review; geographical variations; continuum of care; LEVEL SOCIOECONOMIC-STATUS; URBAN-RURAL DIFFERENCES; NEW-SOUTH-WALES; UNITED-STATES; RADICAL PROSTATECTOMY; POPULATION-DENSITY; HEALTH-CARE; AREA-LEVEL; MULTILEVEL ANALYSIS; RADIATION-THERAPY
Fields of Research : 11 Medical and Health Sciences > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified
Socio-Economic Objective: C Society > 92 Health > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response)
Identification Number or DOI: 10.3389/fonc.2019.00238
URI: http://eprints.usq.edu.au/id/eprint/36286

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