Garcinia Fruits: Their Potential to Combat Metabolic Syndrome

John, Oliver D. and Brown, Lindsay and Panchal, Sunil K. (2019) Garcinia Fruits: Their Potential to Combat Metabolic Syndrome. In: Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery. John Wiley & Sons, Inc., Hoboken, United States, pp. 39-80. ISBN 9781119436676


Abstract

The genus Garcinia belonging to the Clusiaceae family consists of more than 250 species and is traditionally used for diseases such as dysentery, rheumatism, and inflammation; as an antiparasitic or antimicrobial medication; or as food and flavoring. The genus is native to many countries around the tropical region. Phytochemical analyses have identified the presence of α‐mangostin, γ‐mangostin, hydroxycitric acid, guttiferone A, garcinol, morelloflavone, atroviridin, xanthochymol, kolaviron, and 7‐epiclusianones, among other compounds. These compounds may improve health by their antioxidant, anti‐inflammatory, anti‐obesity, and antiproliferative actions. Metabolic syndrome involves increased oxidative stress and chronic low‐grade inflammation to produce conditions including hypertension, hyperglycemia, abdominal obesity, changes in the plasma lipid profile, and non‐alcoholic fatty liver disease, thereby increasing the risk of stroke, diabetes, and heart disease. This chapter will discuss the potential of the bioactive compounds found in Garcinia species as treatments for metabolic syndrome.


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Item Type: Book Chapter (Commonwealth Reporting Category B)
Refereed: Yes
Item Status: Live Archive
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 -)
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 -)
Date Deposited: 06 Aug 2020 05:18
Last Modified: 14 Sep 2020 03:24
Uncontrolled Keywords: Garcina fruits; bioactive compounds; metabolic syndrome; hypertension; hyperglycemia; obesity; fatty liver disease
Fields of Research (2008): 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: https://doi.org/10.1002/9781119436713.ch3
URI: http://eprints.usq.edu.au/id/eprint/36253

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