Liu, Qiufang and Qian, Yuyi and Li, Panli and Zhang, Sihang and Wang, Zerong and Liu, Jianjun and Sun, Xiaoguang and Fulham, Michael and Feng, Dagan and Chen, Zhigang 
ORCID: https://orcid.org/0000-0002-9309-7993 and Song, Shaoli and Lu, Wei and Huang, Gang
(2018)
The combined therapeutic effects of 131 iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer.
Acta Pharmaceutica Sinica B, 8 (3).
pp. 371-380.
ISSN 2211-3835
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Text (Published Version)
The combined therapeutic effects of 131iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer.pdf Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (7MB) | Preview |
Abstract
Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis. In this study, we prepared multifunctional microspheres loading 131I-labeled hollow copper sulfide nanoparticles and paclitaxel (131I-HCuSNPs-MS-PTX) for imaging and therapeutics of W256/B breast tumors in rats. 18F-fluordeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging detected that the expansion of the tumor volume was delayed (P<0.05) following intra-tumoral (i.t.) injection with 131I-HCuSNPs-MS-PTX plus near-infrared (NIR) irradiation. The immunohistochemical analysis further confirmed the anti-tumor effect. The single photon emission computed tomography (SPECT)/photoacoustic imaging mediated by 131I-HCuSNPs-MS-PTX demonstrated that microspheres were mainly distributed in the tumors with a relatively low distribution in other organs. Our results revealed that 131I-HCuSNPs-MS-PTX offered combined photothermal, chemo- and radio-therapies, eliminating tumors at a relatively low dose, as well as allowing SPECT/CT and photoacoustic imaging monitoring of distribution of the injected agents non-invasively. The copper sulfide-loaded microspheres, 131I-HCuSNPs-MS-PTX, can serve as a versatile theranostic agent in an orthotopic breast cancer model.
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| Item Type: | Article (Commonwealth Reporting Category C) |
|---|---|
| Refereed: | Yes |
| Item Status: | Live Archive |
| Additional Information: | This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Faculty/School / Institute/Centre: | Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -) |
| Faculty/School / Institute/Centre: | Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials (1 Jan 2017 -) |
| Date Deposited: | 06 Mar 2019 06:24 |
| Last Modified: | 01 Apr 2019 05:30 |
| Uncontrolled Keywords: | microspheres; theranostics; combination therapy; single photon emission computed tomography/computed tomography (SPECT/CT); photoacoustic imaging |
| Fields of Research (2008): | 09 Engineering > 0912 Materials Engineering > 091205 Functional Materials |
| Fields of Research (2020): | 40 ENGINEERING > 4016 Materials engineering > 401605 Functional materials |
| Funding Details: | |
| Identification Number or DOI: | https://doi.org/10.1016/j.apsb.2018.04.001 |
| URI: | http://eprints.usq.edu.au/id/eprint/36069 |
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