The combined therapeutic effects of 131 iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer

Liu, Qiufang and Qian, Yuyi and Li, Panli and Zhang, Sihang and Wang, Zerong and Liu, Jianjun and Sun, Xiaoguang and Fulham, Michael and Feng, Dagan and Chen, Zhigang and Song, Shaoli and Lu, Wei and Huang, Gang (2018) The combined therapeutic effects of 131 iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer. Acta Pharmaceutica Sinica B, 8 (3). pp. 371-380. ISSN 2211-3835

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Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis. In this study, we prepared multifunctional microspheres loading 131I-labeled hollow copper sulfide nanoparticles and paclitaxel (131I-HCuSNPs-MS-PTX) for imaging and therapeutics of W256/B breast tumors in rats. 18F-fluordeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging detected that the expansion of the tumor volume was delayed (P<0.05) following intra-tumoral (i.t.) injection with 131I-HCuSNPs-MS-PTX plus near-infrared (NIR) irradiation. The immunohistochemical analysis further confirmed the anti-tumor effect. The single photon emission computed tomography (SPECT)/photoacoustic imaging mediated by 131I-HCuSNPs-MS-PTX demonstrated that microspheres were mainly distributed in the tumors with a relatively low distribution in other organs. Our results revealed that 131I-HCuSNPs-MS-PTX offered combined photothermal, chemo- and radio-therapies, eliminating tumors at a relatively low dose, as well as allowing SPECT/CT and photoacoustic imaging monitoring of distribution of the injected agents non-invasively. The copper sulfide-loaded microspheres, 131I-HCuSNPs-MS-PTX, can serve as a versatile theranostic agent in an orthotopic breast cancer model.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: This is an open access article under the CC BY-NC-ND license(
Faculty / Department / School: No Faculty
Date Deposited: 06 Mar 2019 06:24
Last Modified: 01 Apr 2019 05:30
Uncontrolled Keywords: microspheres; theranostics; combination therapy; single photon emission computed tomography/computed tomography (SPECT/CT); photoacoustic imaging
Fields of Research : 09 Engineering > 0912 Materials Engineering > 091205 Functional Materials
Funding Details:
Identification Number or DOI: 10.1016/j.apsb.2018.04.001

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