Graphene-oxide-decorated microporous polyetheretherketone with superior antibacterial capability and in vitro osteogenesis for orthopedic implant

Ouyang, Ling and Deng, Yi and Yang, Lei and Shi, Xiuyuan and Dong, Taosheng and Tai, Youyi and Yang, Weizhong and Chen, Zhi-Gang (2018) Graphene-oxide-decorated microporous polyetheretherketone with superior antibacterial capability and in vitro osteogenesis for orthopedic implant. Macromolecular Bioscience, 18 (6 - Article 1800036). ISSN 1616-5187

Abstract

Due to its similar elastic modulus of human bones, polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity of PEEK limit its wide applications in clinics. In this study, a facile strategy is developed to prepare graphene oxide (GO) modified sulfonated polyetheretherketone (SPEEK) (GO-SPEEK) through a simple dip-coating method. After detailed characterization, it is found that the GO closely deposits on the surface of PEEK, which is attributed to the π–π stacking interaction between PEEK and GO. Antibacterial tests reveal that the GO-SPEEK exhibits excellent suppression toward Escherichia coli. In vitro cell attachment, growth, differentiation, alkaline phosphatase activity, quantitative real-time polymerase chain reaction analyses, and calcium mineral deposition all illustrate that the GO-SPEEK substrate can significantly accelerate the proliferation and osteogenic differentiation of osteoblast-like MG-63 cells compared with those on PEEK and SPEEK groups. These results suggest that the GO-SPEEK has an improved antibacterial activity and cytocompatibility in vitro, showing that the developed GO-SPEEK has a great potential as the bioactive implant material in bone tissue engineering.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Published version cannot be displayed due to copyright restrictions.
Faculty / Department / School: No Faculty
Date Deposited: 06 Mar 2019 05:32
Last Modified: 12 Mar 2019 04:22
Uncontrolled Keywords: antibacterial activity; cytocompatibility; graphene oxide; osteogenic differentiation; polyetheretherketone
Fields of Research : 09 Engineering > 0912 Materials Engineering > 091205 Functional Materials
Funding Details:
Identification Number or DOI: 10.1002/mabi.201800036
URI: http://eprints.usq.edu.au/id/eprint/36068

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