Bioinspired, biocompatible and peptide-decorated silk fibroin coatings for enhanced osteogenesis of bioinert implant

Wang, Chunyan and Wang, Shengnan and Yang, Yuanyi and Jiang, Zhuo and Deng, Yi and Song, Shaoli and Yang, Weizhong and Chen, Zhi-Gang (2018) Bioinspired, biocompatible and peptide-decorated silk fibroin coatings for enhanced osteogenesis of bioinert implant. Journal of Biomaterials Science, Polymer Edition, 29 (13). pp. 1595-1611. ISSN 0920-5063

Abstract

In this study, we develop an osteopromotive polyetheretherketone (PEEK) implant decorated with silk fibroin and bone forming peptide, in which the surface of bioinert PEEK implant is firstly sulfonated to form a three-dimensional, porous topography and then is functionalized with silk fibroin via spin-coating process and peptide decoration. The bio-test results show that cells on the functional bioinert implants exhibit better cell adhesion, proliferation and spreading, when compared with the uncoated ones. Moreover, the peptide-decorated silk fibroin coatings have ability to hasten the osteogenic differentiation and maturation of osteoblast-like cells. Our findings show the potential of the functional PEEK implants with superior bioactivity and osteoinductive property in orthopedics and dentistry. Besides, the facile, bioinspired, osteopromotive modification strategy can be used in other orthopedic and dental implants, such as titanium, zirconium dioxide.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to published version in accordance with the copyright policy of the publisher.
Faculty/School / Institute/Centre: Current - Institute for Advanced Engineering and Space Sciences - Centre for Future Materials
Date Deposited: 06 Mar 2019 04:55
Last Modified: 12 Mar 2019 04:20
Uncontrolled Keywords: bioinert implant, peptide, silk fibroin, porous, PEEK, osteogenesis
Fields of Research : 09 Engineering > 0912 Materials Engineering > 091205 Functional Materials
Funding Details:
Identification Number or DOI: 10.1080/09205063.2018.1477316
URI: http://eprints.usq.edu.au/id/eprint/36063

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