Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats

Bhandarkar, Nikhil S. and Brown, Lindsay and Panchal, Sunil K. (2019) Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats. Nutrition Research, 62. pp. 78-88. ISSN 0271-5317

Abstract

Chlorogenic acid as a constituent of coffee is consumed regularly in the human diet. Chlorogenic acid intake has been associated with decreased risk of cardiovascular disease and type 2 diabetes. We hypothesized that chlorogenic acid would improve cardiovascular, liver, and metabolic responses in a rat model of metabolic syndrome induced by a high-carbohydrate, high-fat diet. Male Wistar rats (8–9-week-old, 335±2g, n=48) were divided into 4 groups and fed with either corn starch diet (16weeks), corn starch diet with chlorogenic acid in food for the last 8weeks, high-carbohydrate, high-fat diet (16weeks), or high-carbohydrate, high-fat diet with chlorogenic acid (~100mg/kg/day) in food for the last 8weeks. In high-carbohydrate, high-fat diet-fed rats, chlorogenic acid reduced energy intake and food efficiency to reduce visceral fat, especially retroperitoneal fat, and abdominal circumference; reversed the elevated systolic blood pressure and attenuated left ventricular diastolic stiffness with reduced collagen deposition and infiltration of inflammatory cells in the left ventricle. Chlorogenic acid decreased inflammation and fat deposition in the liver along with reduced plasma liver enzyme activities of obese rats but did not change the plasma lipid profile. Chlorogenic acid increased diversity of gut microbiota, which may improve overall metabolism in the body. Thus, chronic dietary chlorogenic acid attenuated diet-induced inflammation as well as cardiovascular, liver, and metabolic changes suggesting that chlorogenic acid has potential for further clinical evaluation.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Published version cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Date Deposited: 28 May 2019 01:20
Last Modified: 13 Jun 2019 06:08
Uncontrolled Keywords: chlorogenic acid; obesity; metabolic syndrome; cardiovascular disease; coffee; high-carbohydrate; high-fat diet; gut microbiota
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1016/j.nutres.2018.11.002
URI: http://eprints.usq.edu.au/id/eprint/35645

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