Dual Ag/ZnO-decorated micro-/nanoporous sulfonated polyetheretherketone with superior antibacterial capability and biocompatibility via layer-by-layer self-assembly strategy

Deng, Yi and Yang, Lei and Huang, Xiaobing and Chen, Junhong and Shi, Xiuyuan and Yang, Weizhong and Hong, Min and Wang, Yuan and Dargusch, Matthew and Chen, Zhi-Gang (2018) Dual Ag/ZnO-decorated micro-/nanoporous sulfonated polyetheretherketone with superior antibacterial capability and biocompatibility via layer-by-layer self-assembly strategy. Macromolecular Bioscience, 18 (7 (1800028)). pp. 1-12. ISSN 1616-5187

Abstract

Polyetheretherketone is attractive for dental and orthopedic applications due to its mechanical attributes close to that of human bone; however, the lack of antibacterial capability and bioactivity of polyetheretherketone has substantially impeded its clinical applications. Here, a dual therapy implant coating is developed on the 3D micro-/nanoporous sulfonated polyetheretherketone via layer-by-layer self-assembly of Ag ions and Zn ions. Material characterization studies have indicated that nanoparticles consisting of elemental Ag and ZnO are uniformly incorporated on the porous sulfonated polyetheretherketone surface. The antibacterial assays demonstrate that Ag-decorated sulfonated polyetheretherketone and Ag/ZnO-codecorated sulfonated polyetheretherketone effectively inhibit the reproduction of Gram-negative and Gram-positive bacteria. Owing to the coordination of micro-/nanoscale topological cues and Zn induction, the Ag/ZnO-codecorated sulfonated polyetheretherketone substrates are found to enhance biocompatibility (cell viability, spreading, and proliferation), and hasten osteodifferentiation and -maturation (alkaline phosphate activity (ALP) production, and osteogenesis-related genetic expression), compared with the Ag-decorated sulfonated polyetheretherketone and the ZnO-decorated sulfonated polyetheretherketone counterparts. The dual therapy Ag/ZnO-codecorated sulfonated polyetheretherketone has an appealing bacteriostatic performance and osteogenic differentiation potential, showing great potential for dental and orthopedic implants.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Published version cannot be displayed due to copyright restrictions.
Faculty / Department / School: No Faculty
Date Deposited: 21 Feb 2019 00:21
Last Modified: 06 Mar 2019 05:44
Uncontrolled Keywords: Ag; antibacterial; cytocompatibility; dental and orthopedic implants; polyetheretherketone; ZnO; in-vitro; osteogenic differentiation; bone-formation; biomedical applications; antimicrobial activity; stromal cells; surface; bioactivity; titanium; chitosan
Fields of Research : 03 Chemical Sciences > 0302 Inorganic Chemistry > 030206 Solid State Chemistry
10 Technology > 1007 Nanotechnology > 100708 Nanomaterials
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970109 Expanding Knowledge in Engineering
C Society > 92 Health > 9299 Other Health > 929999 Health not elsewhere classified
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1002/mabi.201800028
URI: http://eprints.usq.edu.au/id/eprint/35488

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