Meta-analysis of histopathological outcomes of laparoscopic assisted rectal resection (LARR) vs open rectal resection (ORR) for carcinoma

Memon, Muhammed Ashraf and Awais, Aiaman and Yunus, Rossita Mohamad and Memon, Breda and Khan, Shahjahan (2018) Meta-analysis of histopathological outcomes of laparoscopic assisted rectal resection (LARR) vs open rectal resection (ORR) for carcinoma. The American Journal of Surgery, 216 (5). pp. 1004-1015. ISSN 0002-9610

Abstract

Background: We conducted a meta-analysis of the randomized evidence to determine the relative merits of histopathological outcomes of laparoscopic assisted (LARR) versus open rectal resection (ORR) forrectal cancer.

Data sources: A search of PubMed and other electronic databases comparing LARR and ORR between Jan 2000 and June 2016 was performed. Histopathological variables analyzed included; location of rectaltumors; complete and incomplete TME; positive and negative circumferential resection margins(þ/-CRM); positive distal resected margins (þDRM); distance of tumor from DRM; number of lymphnodes harvested; resected specimen length; tumor size and perforated rectum.

Results: Fourteen RCTs totaling 3843 patients (LARR = 2096, ORR = 1747) were analyzed. Comparable effects were noted for all these histopathological variables except for the variable perforated rectumwhich favored ORR.

Conclusions: LARR compares favorably to ORR for rectal cancer treatment. However, there is significantlyhigher risk of rectal perforation during LARR compared to ORR.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version, in accordance with the copyright policy of the publisher.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Agricultural, Computational and Environmental Sciences
Date Deposited: 16 Jan 2019 04:29
Last Modified: 24 Jan 2019 04:53
Uncontrolled Keywords: rectal carcinoma; anterior resection; rectal resection; open surgery; laparoscopic surgery; randomized controlled trials; meat-analysis
Fields of Research : 01 Mathematical Sciences > 0104 Statistics > 010402 Biostatistics
11 Medical and Health Sciences > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970101 Expanding Knowledge in the Mathematical Sciences
Identification Number or DOI: 10.1016/j.amjsurg.2018.06.012
URI: http://eprints.usq.edu.au/id/eprint/35383

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