Coffee and caffeine attenuate symptoms of metabolic syndrome in diet-induced obese rats

Panchal, S. and Brown, L. (2012) Coffee and caffeine attenuate symptoms of metabolic syndrome in diet-induced obese rats. In: 2012 Australian & New Zealand Obesity Society Annual Scientific Meeting, 01 Oct 2012, New Zealand.


Aim: Coffee, a rich source of caffeine, chlorogenic acid and diterpenoid alcohols, has been part of the human diet since the 15th century. Pharmacological actions of caffeine include antagonism of adenosine receptors and inhibition of phosphodiesterase activity. A1 adenosine receptors present on adipocytes are involved in control of fatty acid uptake and lipolysis.

Method: This study characterised the effects of Colombian coffee extract and caffeine in a rat model of diet-induced metabolic syndrome. 8—9-Week-old male Wistar rats were divided into two sets of four groups. For each intervention, two groups of rats were fed a corn starch-rich diet whereas the other two groups were given a highcarbohydrate, high-fat diet with 25% fructose in
drinking water for 16 weeks. One group fed each diet was supplemented with 5% aqueous coffee extract or 0.5 g caffeine/kg food for the final 8 week of this protocol.

Results: The high-carbohydrate, high-fat dietfed rats showed the symptoms of metabolic syndrome leading to cardiovascular remodelling and non-alcoholic fatty liver disease. Both coffee extract and caffeine supplementations in highcarbohydrate, high-fat diet-fed rats attenuated impairment in glucose tolerance, hypertension, cardiovascular remodelling and non-alcoholic fatty liver disease. Coffee extract increased body weight without changing dyslipidaemia whereas caffeine reduced body weight and body fat with increases in plasma lipid concentrations.

Conclusion: Coffee extract did not change abdominal fat deposition, so the complex mixture in coffee negates the lipolytic effects of caffeine in adipocytes, likely due to caffeine antagonism of A1 adenosine receptors.

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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Lecture)
Refereed: Yes
Item Status: Live Archive
Additional Information: Abstract only published. Permanent restricted access to Published Abstract in accordance with the copyright policy of the publisher.
Faculty / Department / School: Current - Institute for Agriculture and the Environment
Date Deposited: 27 Nov 2018 05:58
Last Modified: 27 Nov 2018 06:07
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1016/j.orcp.2012.08.039

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