Achacha (Garcinia humilis) rind improves cardiovascular function in rats with diet-induced metabolic syndrome

John, Oliver D. and Wanyonyi, Stephen and Mouatt, Peter and Panchal, Sunil K. and Brown, Lindsay (2018) Achacha (Garcinia humilis) rind improves cardiovascular function in rats with diet-induced metabolic syndrome. Nutrients, 10 (10 - Article 1425).

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Garcinia humilis is a fruit known as achachairú. It is native to South American countries such as Bolivia, Peru, and Brazil, but it is also cultivated as achacha in northern Australia. The aim of this study was to determine the phytochemicals in achacha rind and pulp and to investigate these components as potential treatments for the symptoms of metabolic syndrome. Both rind and pulp contain procyanidins and citric acid rather than hydroxycitric acid. Male Wistar rats (8–9 weeks old) were fed with either high-carbohydrate, high-fat, or corn starch diets for 16 weeks. Intervention groups were fed with either diet supplemented with 1.5% G. humilis rind powder or 2.0% G. humilis pulp for the last 8 weeks of the protocol. Rats fed a high-carbohydrate, high-fat diet exhibited hypertension, dyslipidemia, central obesity, impaired glucose tolerance, and non-alcoholic fatty liver disease. G. humilis rind decreased systolic blood pressure, diastolic stiffness, left ventricular inflammatory cell infiltration, and collagen deposition in high-carbohydrate, high-fat diet-fed rats. However, there was no change in glucose tolerance, body weight, or body composition. Therefore, G. humilis rind, usually a food by-product, but not the edible pulp, showed potential cardioprotection with minimal metabolic changes in a rat model of diet-induced metabolic syndrome.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Date Deposited: 05 Dec 2018 06:41
Last Modified: 10 Dec 2018 04:33
Uncontrolled Keywords: metabolic syndrome; obesity; inflammation; Garcinia humilis; blood pressure; procyanidin; flavonoids
Fields of Research : 06 Biological Sciences > 0606 Physiology > 060603 Animal Physiology - Systems
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
03 Chemical Sciences > 0301 Analytical Chemistry > 030199 Analytical Chemistry not elsewhere classified
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111199 Nutrition and Dietetics not elsewhere classified
Identification Number or DOI: 10.3390/nu10101425

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